中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
10期
33-35
,共3页
肥胖症%儿童%瘦素%脂联素%抵抗素
肥胖癥%兒童%瘦素%脂聯素%牴抗素
비반증%인동%수소%지련소%저항소
Obesity%Child%Leptin%Adiponectin%Resistin
目的 探讨儿童单纯性肥胖程度与脂肪细胞因子瘦素、脂联素和抵抗素水平的关系.方法 选取2～6岁单纯性肥胖儿童110例(肥胖组),其中轻度肥胖组40例,中度肥胖组40例,重度肥胖组30例,另选取正常体重健康儿童40例为对照组,检测空腹血清瘦素、脂联素和抵抗素水平,比较脂肪因子的差异.结果 肥胖组血清瘦素、抵抗素水平明显高于对照组(P<0.01),血清脂联素水平明显低于对照组(P<0.01).中度肥胖组血清瘦素、抵抗素水平明显高于轻度肥胖组[分别为(14.3±1.9)μg/L比(7.8±1.5)μg/L与(14.6±2.2)μg/L比(13.1±3.0)μg/L](P<0.01),脂联素水平明显低于轻度肥胖组[(6.7±3.0)mg/L比(9.1±3.5)mg/L](P<0.01);重度肥胖组血清瘦素、抵抗素水平[分别为(20.4±4.7)、(18.3±3.2)μg/L]明显高于中度肥胖组(P<0.01),脂联素水平[(5.1±1.2)mg/L]明显低于中度肥胖组(P<0.01).结论 儿童脂肪细胞因子水平与肥胖程度密切相关,内脏脂肪堆积可能是造成脂肪因子改变的主要原因之一.
目的 探討兒童單純性肥胖程度與脂肪細胞因子瘦素、脂聯素和牴抗素水平的關繫.方法 選取2～6歲單純性肥胖兒童110例(肥胖組),其中輕度肥胖組40例,中度肥胖組40例,重度肥胖組30例,另選取正常體重健康兒童40例為對照組,檢測空腹血清瘦素、脂聯素和牴抗素水平,比較脂肪因子的差異.結果 肥胖組血清瘦素、牴抗素水平明顯高于對照組(P<0.01),血清脂聯素水平明顯低于對照組(P<0.01).中度肥胖組血清瘦素、牴抗素水平明顯高于輕度肥胖組[分彆為(14.3±1.9)μg/L比(7.8±1.5)μg/L與(14.6±2.2)μg/L比(13.1±3.0)μg/L](P<0.01),脂聯素水平明顯低于輕度肥胖組[(6.7±3.0)mg/L比(9.1±3.5)mg/L](P<0.01);重度肥胖組血清瘦素、牴抗素水平[分彆為(20.4±4.7)、(18.3±3.2)μg/L]明顯高于中度肥胖組(P<0.01),脂聯素水平[(5.1±1.2)mg/L]明顯低于中度肥胖組(P<0.01).結論 兒童脂肪細胞因子水平與肥胖程度密切相關,內髒脂肪堆積可能是造成脂肪因子改變的主要原因之一.
목적 탐토인동단순성비반정도여지방세포인자수소、지련소화저항소수평적관계.방법 선취2～6세단순성비반인동110례(비반조),기중경도비반조40례,중도비반조40례,중도비반조30례,령선취정상체중건강인동40례위대조조,검측공복혈청수소、지련소화저항소수평,비교지방인자적차이.결과 비반조혈청수소、저항소수평명현고우대조조(P<0.01),혈청지련소수평명현저우대조조(P<0.01).중도비반조혈청수소、저항소수평명현고우경도비반조[분별위(14.3±1.9)μg/L비(7.8±1.5)μg/L여(14.6±2.2)μg/L비(13.1±3.0)μg/L](P<0.01),지련소수평명현저우경도비반조[(6.7±3.0)mg/L비(9.1±3.5)mg/L](P<0.01);중도비반조혈청수소、저항소수평[분별위(20.4±4.7)、(18.3±3.2)μg/L]명현고우중도비반조(P<0.01),지련소수평[(5.1±1.2)mg/L]명현저우중도비반조(P<0.01).결론 인동지방세포인자수평여비반정도밀절상관,내장지방퇴적가능시조성지방인자개변적주요원인지일.
Objective To explore the relationship between obesity levels and adipocytokines like leptin,adiponectin and resistin in children.Methods One hundred and ten patients aged 2-6 years with simple obesity were selected into obesity group,which included 40 cases of slight obesity (slight obesity group),40 cases of medium obesity (medium obesity group) and 30 cases of severe obesity (severe obesity group).Forty cases of healthy children with normal bodyweight were included in control group.Their serum leptin,adiponectin and resistin levels were tested and compared.Results Serum leptin and resistin levels in obesity group were remarkably higher than those in control group (P < 0.01),whereas adiponectin level was much lower than that in control group (P< 0.01).Serum leptin and resistin levels in medium obesity group were remarkably higher than those in slight obesity group [(14.3 ±1.9) μg/L vs (7.8 ± 1.5)μg/L and (14.6±2.2) μg/Lvs (13.1 ±3.0) μg/L](P< 0.01),whereas adiponectin level was much lower than that in slight obesity group[(6.7 ± 3.0) mg/L vs (9.1 ± 3.5) mg/L](P< 0.01).Serum leptin and resistin levels in severe obesity group [(20.4 ±4.7),(18.3 ±3.2) μg/L]were remarkably higher than those in medium obesity group(P< 0.01),whereas adiponectin level [(5.1 ± 1.2) mg/L]was much lower than that in medium obesity group (P< 0.01).Conclusion The levels of adipocytokines are closely correlated with obesity level in children,especially for abdominal obesity.
