CAJ | 학술논문

目的探讨不同年龄成年人急性白血病(AL)的形态学、免疫学及细胞遗传学(MIC)特征.方法 172例初诊AL成年患者按年龄分为两组:非老年组(年龄＜60岁)及老年组(年龄≥60岁),进行MIC分型比较.结果老年组中M3的比例显著低于非老年组16.0%(3/50):18.9%(23/122)](P＜0.05).老年组骨髓增生低下或极度低下的比例显著高于非老年组[14.0%(7/50):4.1%(5/122)](P＜0.05),而增生明显至极度活跃的比例显著低于非老年组[52.0%(26/50):73.8%(90/122)](P＜0.05).老年组急性髓细胞白血病(AML)患者中,伴淋系抗原表达的AML(Ly+AML)比例显著高于非老年组[63.4%(26/41):41.3%(38/92)](P＜0.05).老年组AML患者中,高危组核型比例显著高于非老年组[33.3%(11/33):14.1%(10/71)](P＜0.05).结论年龄是AL的重要预后因素,老年AL患者的预后总体较非老年AL患者为差.
목적 탐토불동년령성년인급성백혈병(AL)적형태학、면역학급세포유전학(MIC)특정.방법 172례초진AL성년환자안년령분위량조:비노년조(년령＜60세)급노년조(년령≥60세),진행MIC분형비교.결과 노년조중M3적비례현저저우비노년조16.0%(3/50):18.9%(23/122)](P＜0.05).노년조골수증생저하혹겁도저하적비례현저고우비노년조[14.0%(7/50):4.1%(5/122)](P＜0.05),이증생명현지겁도활약적비례현저저우비노년조[52.0%(26/50):73.8%(90/122)](P＜0.05).노년조급성수세포백혈병(AML)환자중,반림계항원표체적AML(Ly+AML)비례현저고우비노년조[63.4%(26/41):41.3%(38/92)](P＜0.05).노년조AML환자중,고위조핵형비례현저고우비노년조[33.3%(11/33):14.1%(10/71)](P＜0.05).결론 년령시AL적중요예후인소,노년AL환자적예후총체교비노년AL환자위차.
Objective To investigate the characters of morphology,immunology and cytogenetics of adult acute leukemia (AL) in different ages. Methods 172 cases of newly diagnosed adult AL were divided into two groups:the non-aged group (age＜60 years) and the aged group ( age≥60 years). Morphology,immunology and cytogenetics between the two groups were compared. Results The incidence of M3 in aged AL was significantly lower than that in non-aged AL[6.0 %(3/50) vs 18.9 %(23/122),P ＜0.05]. The incidence of hypo-or extremely hypo-cellular AL in aged AL was significantly higher than that in non-aged AL[14.0 %(7/50) vs 4.1 %(5/122),P ＜0.05],but the incidence of hyper-or extremely hyper-cellular was significantly lower than that in non-aged AL[52.0 %(26/50) vs 73.8 %(90/122),P ＜0.05]. Among aged acute myeloid leukemia (AML),the incidence of lymphoid antigen positive AML (Ly+AML) was significantly higher than that in non-aged AML[63.4 %(26/41) vs 41.3 %(38/92),P ＜0.05]. The incidence of adverse karyotypes in aged AML was significantly higher than that in non-aged AML[33.3 %(11/33) vs 14.1 %(10/71),P ＜0.05].Conclusion Age is an important prognostic factor in AL. Generally,aged AL has poorer prognosis than nonaged AL.