CAJ | 학술논문

支气管哮喘(简称哮喘)的发病过程中,气道平滑肌细胞在哮喘相关的炎症介质的作用下,出现肥大、增殖活性增强、凋亡减少、迁移、表型转变及动力学异常等改变.此种气道平滑肌的异常最终导致了气道阻力增加和气道高反应性.因此,深入了解导致气道平滑肌异常的表现及机制,寻找更加合理有效的治疗靶点,将是未来哮喘治疗的新方向.
지기관효천(간칭효천)적발병과정중,기도평활기세포재효천상관적염증개질적작용하,출현비대、증식활성증강、조망감소、천이、표형전변급동역학이상등개변.차충기도평활기적이상최종도치료기도조력증가화기도고반응성.인차,심입료해도치기도평활기이상적표현급궤제,심조경가합리유효적치료파점,장시미래효천치료적신방향.
Airway smooth muscle cells underwent hyperplasia, hypertrophy, hypoapoptosis and abnormal migration, phenotype switch and mechanical contraction in the process of asthma. Such abnormalities eventually resulted in high airway resistance and airway hyperreactivity. It is important to figure out the mechanisms underlining these abnormalities and to identify more reasonable and effective target for future therapeutic usage.