中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
6期
21-23
,共3页
HIV%AIDS%CD4+T淋巴细胞计数%外周血淋巴细胞～总数%变量%相关性
HIV%AIDS%CD4+T淋巴細胞計數%外週血淋巴細胞～總數%變量%相關性
HIV%AIDS%CD4+T림파세포계수%외주혈림파세포～총수%변량%상관성
HIV%AIDS%CD4 Lymphocyte Count%Peripheral blood total lymphocyte count%Variance%correlation
目的 研究人免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者CD4+T淋巴细胞数的变化(△CD4+T)和外周血淋巴细胞总数的变量(△TLC)的相关性,探讨用△TLC预测CD4+T在监测HIV疾病进展和高效抗逆转录病毒治疗(HAART)疗效中发挥的作用.方法 分析91例HIV/AIDS患者CD4+T和TLC及△CD4+T和△TLC的相关性,通过ROC面积、敏感度、特异度、阳性预测值和阴性预测值分析,寻找能有效预测CD4+T淋巴细胞数<200 个/μl,<350个/μl,时TLC的范围;△CD4+T淋巴细胞数为50个/μl、100个/μl、200个/μl、300个/μl时△TLC的范围.结果 91例HIV/AIDS患者CD4+T和TLC相关系数r为0.716,P<0.01;△TLC和△CD4+T具有更强的相关性,相关系数r为0.809,P<0.01.用1300个/μl和1700个/μl TLC预测CD4+T 200个/μl和350个/μl具有显著的预测价值.用△TLC 170个/μl、330个/μl、630个/μl、910个/μl分别预测△CD4+T 50个/μl、100个/μl、200个/μl、300个/μl,各项预测指标基本上在90%以上,显著高于相同时间下TLC预测CD4+T的效果.结论 人免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者CD4+T淋巴细胞数的变化(△CD4+T)和外周血淋巴细胞总数的变量(△TLC)具有直线相关性.在条件匮乏的艾滋病高发区,可以应用△TLC预测△CD4+T,比TLC更加直观、准确的反映HIV感染者疾病进展和评价AIDS患者HAART的疗效.
目的 研究人免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者CD4+T淋巴細胞數的變化(△CD4+T)和外週血淋巴細胞總數的變量(△TLC)的相關性,探討用△TLC預測CD4+T在鑑測HIV疾病進展和高效抗逆轉錄病毒治療(HAART)療效中髮揮的作用.方法 分析91例HIV/AIDS患者CD4+T和TLC及△CD4+T和△TLC的相關性,通過ROC麵積、敏感度、特異度、暘性預測值和陰性預測值分析,尋找能有效預測CD4+T淋巴細胞數<200 箇/μl,<350箇/μl,時TLC的範圍;△CD4+T淋巴細胞數為50箇/μl、100箇/μl、200箇/μl、300箇/μl時△TLC的範圍.結果 91例HIV/AIDS患者CD4+T和TLC相關繫數r為0.716,P<0.01;△TLC和△CD4+T具有更彊的相關性,相關繫數r為0.809,P<0.01.用1300箇/μl和1700箇/μl TLC預測CD4+T 200箇/μl和350箇/μl具有顯著的預測價值.用△TLC 170箇/μl、330箇/μl、630箇/μl、910箇/μl分彆預測△CD4+T 50箇/μl、100箇/μl、200箇/μl、300箇/μl,各項預測指標基本上在90%以上,顯著高于相同時間下TLC預測CD4+T的效果.結論 人免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者CD4+T淋巴細胞數的變化(△CD4+T)和外週血淋巴細胞總數的變量(△TLC)具有直線相關性.在條件匱乏的艾滋病高髮區,可以應用△TLC預測△CD4+T,比TLC更加直觀、準確的反映HIV感染者疾病進展和評價AIDS患者HAART的療效.
목적 연구인면역결함병독(HIV)감염자화애자병(AIDS)환자CD4+T림파세포수적변화(△CD4+T)화외주혈림파세포총수적변량(△TLC)적상관성,탐토용△TLC예측CD4+T재감측HIV질병진전화고효항역전록병독치료(HAART)료효중발휘적작용.방법 분석91례HIV/AIDS환자CD4+T화TLC급△CD4+T화△TLC적상관성,통과ROC면적、민감도、특이도、양성예측치화음성예측치분석,심조능유효예측CD4+T림파세포수<200 개/μl,<350개/μl,시TLC적범위;△CD4+T림파세포수위50개/μl、100개/μl、200개/μl、300개/μl시△TLC적범위.결과 91례HIV/AIDS환자CD4+T화TLC상관계수r위0.716,P<0.01;△TLC화△CD4+T구유경강적상관성,상관계수r위0.809,P<0.01.용1300개/μl화1700개/μl TLC예측CD4+T 200개/μl화350개/μl구유현저적예측개치.용△TLC 170개/μl、330개/μl、630개/μl、910개/μl분별예측△CD4+T 50개/μl、100개/μl、200개/μl、300개/μl,각항예측지표기본상재90%이상,현저고우상동시간하TLC예측CD4+T적효과.결론 인면역결함병독(HIV)감염자화애자병(AIDS)환자CD4+T림파세포수적변화(△CD4+T)화외주혈림파세포총수적변량(△TLC)구유직선상관성.재조건궤핍적애자병고발구,가이응용△TLC예측△CD4+T,비TLC경가직관、준학적반영HIV감염자질병진전화평개AIDS환자HAART적료효.
Objective To analyze the correlation between the change of CD4 + T lymphocyte count (△CD4 +T) and the variance of peripheral blood total lymphocyte count(△TLC) and evaluate the effect of △TLC to substitute for CD4 +T count to predict HIV progression monitoring and the curative effect on clinical HAART treatment in HIV/AIDS patients. Methods Study the correlation between TLC and CD4 + T count and the correlation between △TLC and △CD4 + T count in 91 patients with HIV/AIDS. Study the date of ROC are-a, sensitivity, specificity, positive predictive value and negative predictive value for CD4 + T 200/μl, 350/μl to find the extent of TLC. Study the date of ROC area, sensitivity, specificity, positive predictive value and negative predictive value for △CD4 +T 50/μl、100/μl、200/μl、300/μl to find the extent of △TLC. Results The sig-nificant correlation (r value) between TLC and CD4 + T count was 0.716(P<0.01) in the patients. The re-markable dynamical correlations between△TLC and △CD4 + T were found comparing to that between TLC and CD4 + T count r value was 0.809(P<0.01). It was significant value in prediction CD4 + T count 200/μl and 350/μl with TLC cut-off 1300/μl and 1700/μl. Moreover,as more significant market to predict optimal △CD4 +T for 50/μl,100/μl,200/μl,for300/μl, △TLC were 170/μl,330/μl,630/μl,910/μl respectively. Conclu-sion There is straight line correlation between the change of CD4 + T cell counts and the variance of total lym-phocyte counts in HIV/AIDS patients. TLC especially △TLC for prediction of △CD4 + T can be available as a substitute method to estimate HIV disease progression and clinical HAART in some resource-constrained area of China.
