CAJ | 학술논문

目的调查手术去势对晚期前列腺癌患者生活质量的影响.方法采用EORTCQLQ-C30总量表和QLQ-PR25子量表调查69例接受手术去势的晚期前列腺癌患者患病前、治疗后6个月和治疗后12个月3个时闯点的生活质量情况.结果手术去势虽然能缓解全身或局部疼痛(P＜0.01),并改善排尿症状(P＜0.01),且患者感觉总体健康状况有好转(P＜0.01),但术后患者躯体(P＜0.05)、角色(P＜0.01)、情绪(P＜0.01)、认知(P＜0.05)、社会(P＜0.05或＜0.01)等功能均有不同程度下降,且失眠增多(P＜0.05)、疲倦加剧(P＜0.01),治疗相关症状如潮红与乳房胀痛等显著出现(P＜0.01),性趣明显下降甚至丧失(P＜0.01),特别是彻底丧失了正常的性生活.结论手术去势对前列腺癌患者的机体与心理均有不同程度的影响,尤其是性功能方面有不可逆性损害.
목적 조사수술거세대만기전렬선암환자생활질량적영향.방법 채용EORTCQLQ-C30총량표화QLQ-PR25자량표조사69례접수수술거세적만기전렬선암환자환병전、치료후6개월화치료후12개월3개시틈점적생활질량정황.결과 수술거세수연능완해전신혹국부동통(P＜0.01),병개선배뇨증상(P＜0.01),차환자감각총체건강상황유호전(P＜0.01),단술후환자구체(P＜0.05)、각색(P＜0.01)、정서(P＜0.01)、인지(P＜0.05)、사회(P＜0.05혹＜0.01)등공능균유불동정도하강,차실면증다(P＜0.05)、피권가극(P＜0.01),치료상관증상여조홍여유방창통등현저출현(P＜0.01),성취명현하강심지상실(P＜0.01),특별시철저상실료정상적성생활.결론 수술거세대전렬선암환자적궤체여심리균유불동정도적영향,우기시성공능방면유불가역성손해.
Objective To investigate the quality of life in man after treatment of advanced prostate cancer by surgical castration. Methods A total of 69 patients with advanced prostate cancer treated by sur-gical castration completed the European organization for research and treatment of cancer quality of life questionnaire (QLQ-C30) and QLQ-prostate specific 25-item (PR25) module third at a 12-month interval.The assessment points were preoporative,6 months postoperative and 12 months postoperative. Results Although there were improvement on pain relief (P ＜ 0.01 ) and symptom of urinary (P ＜ 0.01 ) and global health (P ＜ 0.01 ), the physical functioning (P ＜ 0.05 ), role functioning (P ＜ 0.01 ), emotional functioning (P ＜ 0.01 ), cognitive functioning (P ＜ 0.05 ), social functioning (P ＜ 0.05 or ＜ 0.01 ) were found significantly reduced , and insomnia (P ＜ 0.05) and fatigue (P ＜ 0.01 ) aggravated, treatment related symptoms (P ＜0.01 )appeared predominantly, especially deprivation of sexual functioning. Conclusion The surgical cas-tration when treating advanced prostate cancer did appear to impair the physical and psychological of patients, especially the sexual functioning.