中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2012年
3期
250-252
,共3页
张俊%路新国%李湘蕾%周桂芬%胡雁%韩春锡%肖宇寒%陈伟艳%陈彦%廖建湘
張俊%路新國%李湘蕾%週桂芬%鬍雁%韓春錫%肖宇寒%陳偉豔%陳彥%廖建湘
장준%로신국%리상뢰%주계분%호안%한춘석%초우한%진위염%진언%료건상
癫痫%左乙拉西坦%脑电图%儿童
癲癇%左乙拉西坦%腦電圖%兒童
전간%좌을랍서탄%뇌전도%인동
Epilepsy%Levetiracetam%Electrocoricogram%Children
目的 探讨左乙拉西坦对临床发作缓解而脑电图明显异常的癫痫患儿的脑电图的影响.方法 将就诊于我院神经专科门诊临床发作得到控制1年以上而脑电图依然明显异常的39例卡马西平单药治疗中的部分性或复杂部分性发作的癫痫患儿按来诊顺序交叉分为对照组、丙戊酸钠组及左乙拉西坦组,各13例.入组前半个月内均行脑电图检查,入组后分别予以维持原药治疗、加用丙戊酸钠口服及加用左乙拉西坦口服.观察时间6个月,6个月后复查脑电图,分析其疗效.结果 3组患儿脑电图改善率(控制+显效+有效/总例数-失访人数)分别为9.1％、23.1％和66.7％；3组患儿脑电图改善率比较差异有统计学意义(P＜0.01),丙戊酸钠组与对照组比较差异无统计学意义(P＞0.0125),左乙拉西坦组与对照组比较差异有统计学意义(P＜0.012 5).结论 添加左乙拉西坦可以有效减少癫痫患儿发作间期脑电图异常放电频率.
目的 探討左乙拉西坦對臨床髮作緩解而腦電圖明顯異常的癲癇患兒的腦電圖的影響.方法 將就診于我院神經專科門診臨床髮作得到控製1年以上而腦電圖依然明顯異常的39例卡馬西平單藥治療中的部分性或複雜部分性髮作的癲癇患兒按來診順序交扠分為對照組、丙戊痠鈉組及左乙拉西坦組,各13例.入組前半箇月內均行腦電圖檢查,入組後分彆予以維持原藥治療、加用丙戊痠鈉口服及加用左乙拉西坦口服.觀察時間6箇月,6箇月後複查腦電圖,分析其療效.結果 3組患兒腦電圖改善率(控製+顯效+有效/總例數-失訪人數)分彆為9.1％、23.1％和66.7％；3組患兒腦電圖改善率比較差異有統計學意義(P＜0.01),丙戊痠鈉組與對照組比較差異無統計學意義(P＞0.0125),左乙拉西坦組與對照組比較差異有統計學意義(P＜0.012 5).結論 添加左乙拉西坦可以有效減少癲癇患兒髮作間期腦電圖異常放電頻率.
목적 탐토좌을랍서탄대림상발작완해이뇌전도명현이상적전간환인적뇌전도적영향.방법 장취진우아원신경전과문진림상발작득도공제1년이상이뇌전도의연명현이상적39례잡마서평단약치료중적부분성혹복잡부분성발작적전간환인안래진순서교차분위대조조、병무산납조급좌을랍서탄조,각13례.입조전반개월내균행뇌전도검사,입조후분별여이유지원약치료、가용병무산납구복급가용좌을랍서탄구복.관찰시간6개월,6개월후복사뇌전도,분석기료효.결과 3조환인뇌전도개선솔(공제+현효+유효/총례수-실방인수)분별위9.1％、23.1％화66.7％；3조환인뇌전도개선솔비교차이유통계학의의(P＜0.01),병무산납조여대조조비교차이무통계학의의(P＞0.0125),좌을랍서탄조여대조조비교차이유통계학의의(P＜0.012 5).결론 첨가좌을랍서탄가이유효감소전간환인발작간기뇌전도이상방전빈솔.
Objective This clinical study is aimed to investigate whether levetiracetam (LEV) can improve electrocorticogram (EEG) in epileptic children epilepsy patients with better clinical manifestation but abnormal EEG findings.Methods Totally 39 children from our neurological clinic with partial or complex partial epilepsy seizure were included in present study and assigned equally into three groups receiving different treatment:control group,sodium valproate (VPA) group,and LEV group.Their clinical symptoms had been controlled for over one year by carbamazepine ( CBZ),but EEG results showed clearly abnormal.Epileptiform discharges were observed in routine EEG exams half a month before recruiting.After recruiting,they continued to receive CBZ alone (control group) or co-treated with VPA ( VPA group) or LEV (LEVgroup),respectively.Six months later,EEG was taken again and results were analyzed.Results Improvement rate were 9.1％ ( control group),23.1％ ( VPA group),and 66.7％ (LEV group),respectively;Overall statistical difference was reached among three groups ( P＜0.01 ) and between control group and LEV group( P＜0.012 5 ),but no statistical difference between control group and VPA group was reached ( P＞0.0125).Conclusion Co-treatment of LEV in child epilepsy patients receiving CBZ can significantly decrease abnormal EEG discharge frequency during interictal period.
