CAJ | 학술논문

目的观察小鼠口服五味子宁神口服液的急性毒性反应.方法采用最大给药量法测定小鼠口服五味子宁神口服液的急性毒性;以200 g生药·kg-1·d-1的五味子宁神口服液(相当于临床用量156.3倍)灌胃,连续2周,观察小鼠的生长发育、体质量和主要脏器指数的变化.结果小鼠一般状况、体质量增长、主要脏器系数均无明显差异或异常.结论五昧子宁神口服液临床用药范围内应用是比较安全的.
목적 관찰소서구복오미자저신구복액적급성독성반응.방법 채용최대급약량법측정소서구복오미자저신구복액적급성독성;이200 g생약·kg-1·d-1적오미자저신구복액(상당우림상용량156.3배)관위,련속2주,관찰소서적생장발육、체질량화주요장기지수적변화.결과 소서일반상황、체질량증장、주요장기계수균무명현차이혹이상.결론 오매자저신구복액림상용약범위내응용시비교안전적.
Objective To abserve the acute toxicity in mice administered with Wuweizi Ningshen oral liquid.Methods The maximum administration dosage(MAD)of Wuweizi Ningshen oral liquid were determined by administration intragastricly in mice.Wuweizi Ningshen oral liquid was administered for 2 weeks,and the growth condition,body weight growth and index of main viscera were measured.Results The index of growth condition,body weight growth and index of main viscera were in normal ranges.Conclusion It could be concluded that Wuweizi Ningshen oral liquid is safe to be administered in the dose prescribed.