中华超声影像学杂志
中華超聲影像學雜誌
중화초성영상학잡지
CHINESE JOURNAL OF ULTRASONOGRAPHY
2011年
9期
808-810
,共3页
许杨青%陈欣林%扬小红%路小军%陈佩文%黄君红%胡蕾%黄程%陆兆龄
許楊青%陳訢林%颺小紅%路小軍%陳珮文%黃君紅%鬍蕾%黃程%陸兆齡
허양청%진흔림%양소홍%로소군%진패문%황군홍%호뢰%황정%륙조령
超声检查%微气泡%高血压,妊娠性%胎盘%血液动力学现象
超聲檢查%微氣泡%高血壓,妊娠性%胎盤%血液動力學現象
초성검사%미기포%고혈압,임신성%태반%혈액동역학현상
Ultrasonography%Microbubbles%Hypertension,pregnancy-induced%Placenta%Hemodynamic phenomena
目的 探讨妊娠高血压综合征模型母鼠胎盘超声造影(CPS)测量血流灌注参数与肿瘤病理微血管密度(MVD)的相关性。方法 制作34只妊娠高血压综合征母鼠动物模型并行超声造影，造影后应用SonoLiver1.025分析软件绘制胎盘的造影时间-强度曲线(TIC),得出妊娠高血压综合征模型母鼠造影定量血流灌注参数达峰时间(TTP)、峰值强度(Imax)、曲线下面积(AUC)及总灌注量(V)；以上所得参数与造影后病理组织免疫组化染色计测的MVD进行相关性分析。结果 34只妊娠高血压综合征母鼠胎盘组织TTP为(14.55±3.45)s，Imax为(20.83±6.15)dB，AUC为(1868.61±25.76) dB，V为(58.01±23.56)dB;造影后病理MVD为88.98±24.78;妊娠高血压综合征模型母鼠胎盘Imax与MVD呈正相关(r =0.885，P=0.000)，AUC与MVD呈正相关(r=0.677，P=0.001)，V与MVD呈正相关(r=0.877，P=0.000)，TTP与MVD无相关关系。结论妊娠高血压综合征模型母鼠超声造影Imax、AUC、V与胎盘MVD相关良好，是测量评价妊娠高血压综合征母鼠胎盘血流灌注的可靠依据。
目的 探討妊娠高血壓綜閤徵模型母鼠胎盤超聲造影(CPS)測量血流灌註參數與腫瘤病理微血管密度(MVD)的相關性。方法 製作34隻妊娠高血壓綜閤徵母鼠動物模型併行超聲造影，造影後應用SonoLiver1.025分析軟件繪製胎盤的造影時間-彊度麯線(TIC),得齣妊娠高血壓綜閤徵模型母鼠造影定量血流灌註參數達峰時間(TTP)、峰值彊度(Imax)、麯線下麵積(AUC)及總灌註量(V)；以上所得參數與造影後病理組織免疫組化染色計測的MVD進行相關性分析。結果 34隻妊娠高血壓綜閤徵母鼠胎盤組織TTP為(14.55±3.45)s，Imax為(20.83±6.15)dB，AUC為(1868.61±25.76) dB，V為(58.01±23.56)dB;造影後病理MVD為88.98±24.78;妊娠高血壓綜閤徵模型母鼠胎盤Imax與MVD呈正相關(r =0.885，P=0.000)，AUC與MVD呈正相關(r=0.677，P=0.001)，V與MVD呈正相關(r=0.877，P=0.000)，TTP與MVD無相關關繫。結論妊娠高血壓綜閤徵模型母鼠超聲造影Imax、AUC、V與胎盤MVD相關良好，是測量評價妊娠高血壓綜閤徵母鼠胎盤血流灌註的可靠依據。
목적 탐토임신고혈압종합정모형모서태반초성조영(CPS)측량혈류관주삼수여종류병리미혈관밀도(MVD)적상관성。방법 제작34지임신고혈압종합정모서동물모형병행초성조영，조영후응용SonoLiver1.025분석연건회제태반적조영시간-강도곡선(TIC),득출임신고혈압종합정모형모서조영정량혈류관주삼수체봉시간(TTP)、봉치강도(Imax)、곡선하면적(AUC)급총관주량(V)；이상소득삼수여조영후병리조직면역조화염색계측적MVD진행상관성분석。결과 34지임신고혈압종합정모서태반조직TTP위(14.55±3.45)s，Imax위(20.83±6.15)dB，AUC위(1868.61±25.76) dB，V위(58.01±23.56)dB;조영후병리MVD위88.98±24.78;임신고혈압종합정모형모서태반Imax여MVD정정상관(r =0.885，P=0.000)，AUC여MVD정정상관(r=0.677，P=0.001)，V여MVD정정상관(r=0.877，P=0.000)，TTP여MVD무상관관계。결론임신고혈압종합정모형모서초성조영Imax、AUC、V여태반MVD상관량호，시측량평개임신고혈압종합정모서태반혈류관주적가고의거。
Objective To investigate the correlation between quantitative parameters with contrastenhanced ultrasound (CEUS) and microvessel density (MVD).Methods Thirty-four placenta of rat model of preeclampsia underwent CEUS examination.The peak intensity time curves on the enhanced images were analyzed quantitatively with computer to get quantitative parameters[the time to peak(TTP), maximal peak intensity(Imax), the area under curve(AUC) and the mean perfusion volume(V)].These parameters were compared with MVD counted with immunohistochemistry and the correlation was statistically studied.Results The TTP in the enhanced images was (14.55 ± 3.45)s, Imax was (20.83 ± 6.15) dB, AUC was (1868.61 ± 25.76)dB, V was (58.01 ± 23.56)dB, and the MVD of placenta of rat model of preeclampsia was (88.98 ± 24.78) in 34 rats.The Imax was correlated positively to MVD (r = 0.885, P = 0.000) ,AUC was correlated positively to MVD (r = 0.677, P = 0.001), V was correlated positively to MVD (r =0.877, P = 0.000).There was no correlation between TTP and MVD in lesions.Conclusions The Imax,AUC and V calculated with CEUS were correlated to MVD, these parameters were valuable index for quantitative evaluation of placental blood perfusion.
