中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2008年
7期
430-432
,共3页
赵燕%张福杰%豆智慧%程跃武%唐志荣%刘爱文%彭国平%乔晓春%赵红心%庞琳%云鹰%刘中夫
趙燕%張福傑%豆智慧%程躍武%唐誌榮%劉愛文%彭國平%喬曉春%趙紅心%龐琳%雲鷹%劉中伕
조연%장복걸%두지혜%정약무%당지영%류애문%팽국평%교효춘%조홍심%방림%운응%류중부
儿童%获得性免疫缺陷综合征%人类免疫缺陷病毒
兒童%穫得性免疫缺陷綜閤徵%人類免疫缺陷病毒
인동%획득성면역결함종합정%인류면역결함병독
Children%Acquired immunodefieiency syndrome%Human immunodeficieney virus
目的 研究15岁以下AIDS患者的临床特点,了解HIV对患儿的影响.方法 分析275例即将入选接受高效抗反转录病毒治疗患者的临床资料,对人口学、流行病学、临床分期、实验室特点及生长发育状况进行分析.结果 275例AIDS患者主要以母婴途径传播为主,占78.9%,输血及血制品传播的为16.0%.平均年龄(7.6±3.7)岁,其中1岁以内5例,1～5岁104例,6岁以上166例.世界卫生组织临床3期和4期的占70.1%,6岁以上患儿的平均CD4细胞计数为(137±159)/μL,1岁以内患儿为(1 246±776)/μL.1～5岁患儿为(304±317)/μL,181例患者伴有不同程度的贫血.患者主要表现为持续发热、皮肤损害、慢性腹泻、鹅口疮及反复上呼吸道感染等.对生长发育影响显示:身高低于x-2s占49.6%,体质量低于x-2s占19.9%.结论 现存活的AIDS儿童以6岁以上为主,HIV对儿童感染者的免疫功能、临床进展、生长发育均有显著影响.
目的 研究15歲以下AIDS患者的臨床特點,瞭解HIV對患兒的影響.方法 分析275例即將入選接受高效抗反轉錄病毒治療患者的臨床資料,對人口學、流行病學、臨床分期、實驗室特點及生長髮育狀況進行分析.結果 275例AIDS患者主要以母嬰途徑傳播為主,佔78.9%,輸血及血製品傳播的為16.0%.平均年齡(7.6±3.7)歲,其中1歲以內5例,1～5歲104例,6歲以上166例.世界衛生組織臨床3期和4期的佔70.1%,6歲以上患兒的平均CD4細胞計數為(137±159)/μL,1歲以內患兒為(1 246±776)/μL.1～5歲患兒為(304±317)/μL,181例患者伴有不同程度的貧血.患者主要錶現為持續髮熱、皮膚損害、慢性腹瀉、鵝口瘡及反複上呼吸道感染等.對生長髮育影響顯示:身高低于x-2s佔49.6%,體質量低于x-2s佔19.9%.結論 現存活的AIDS兒童以6歲以上為主,HIV對兒童感染者的免疫功能、臨床進展、生長髮育均有顯著影響.
목적 연구15세이하AIDS환자적림상특점,료해HIV대환인적영향.방법 분석275례즉장입선접수고효항반전록병독치료환자적림상자료,대인구학、류행병학、림상분기、실험실특점급생장발육상황진행분석.결과 275례AIDS환자주요이모영도경전파위주,점78.9%,수혈급혈제품전파적위16.0%.평균년령(7.6±3.7)세,기중1세이내5례,1～5세104례,6세이상166례.세계위생조직림상3기화4기적점70.1%,6세이상환인적평균CD4세포계수위(137±159)/μL,1세이내환인위(1 246±776)/μL.1～5세환인위(304±317)/μL,181례환자반유불동정도적빈혈.환자주요표현위지속발열、피부손해、만성복사、아구창급반복상호흡도감염등.대생장발육영향현시:신고저우x-2s점49.6%,체질량저우x-2s점19.9%.결론 현존활적AIDS인동이6세이상위주,HIV대인동감염자적면역공능、림상진전、생장발육균유현저영향.
Objective To study the clinical characteristic of acquired immune deficiency syndrome (AIDS) patients younger than 15 years old and to explore the influence of human immunodeficiency virus (HIV) infection on them. Methods The clinical information, including demographic profile, clinical stages of the disease, laboratory test results and developmental status were gathered from 275 antiretroviral therapy naive patients. Results Seventy eight point nine percent patients were infected by vertical transmission. Sixteen percent were infected by receiving blood products. The average age was (7.6±3. 7) years, with 5 cases younger than 1 year old, 104 cases ranging from 1 - 5 years and 166 cases elder than 6 years. Seventy point one percent patients were classified as stage 3 or 4 according to World Health Organization definitions. The average CD4 count was ( 137 ± 159 )/μL, ( 304 ± 317 ) /μL and ( 1 246 ± 776 )/μL respectively in children elder than 6 years, ranging from 1 to 5 years and younger than 1 year. One hundred and eighty one cases suffered from anemia on different severity grading. The most common HIV related symdromes included persistent fever, skin damage, persistent diarrhea, oral candidiasis and recurrent upper respiratory tract infection. Among these infected children, 49. 6% showed height lower than x - 2s and 19. 9% showed weight lower than x - 2s. Conclusions Most survival pediatric AIDS patients are elder than 6 years. HIV infection can significantly affect the children's immune system function,growth and development.
