CAJ | 학술논문

目的观察卡培他滨(希罗达)联合奥沙利铂治疗晚期大肠癌的临床疗效和耐受性.方法经病理证实的Ⅲ期和Ⅳ期大肠癌患者20例,每天口服卡他滨2000mg/m2,第1～14天;奥沙利铂130mg/m2,静滴,第1天;每3周为1个治疗周期,连用2个周期以上评价疗效.结果 20例患者,其中CR 1例,PR 7例,NC 10例,PD 2例,总有效率40.0%.主要不良反应为Ⅰ～Ⅱ度的骨髓抑制、恶心呕叶、腹泻、口腔粘膜炎、感觉神经病变和手足综合征,无严重的化疗相关不良反应.结论卡培他滨联合奥沙利铂治疗晚期大肠癌疗效确切,安全性好,副作用可耐受,是治疗晚期大肠癌的有效方法 ,值得临床推广.
목적 관찰잡배타빈(희라체)연합오사리박치료만기대장암적림상료효화내수성.방법 경병리증실적Ⅲ기화Ⅳ기대장암환자20례,매천구복잡타빈2000mg/m2,제1～14천;오사리박130mg/m2,정적,제1천;매3주위1개치료주기,련용2개주기이상평개료효.결과 20례환자,기중CR 1례,PR 7례,NC 10례,PD 2례,총유효솔40.0%.주요불량반응위Ⅰ～Ⅱ도적골수억제、악심구협、복사、구강점막염、감각신경병변화수족종합정,무엄중적화료상관불량반응.결론 잡배타빈연합오사리박치료만기대장암료효학절,안전성호,부작용가내수,시치료만기대장암적유효방법 ,치득림상추엄.
Objective To investigate the therapeutic effect and tolerability of capecitabine combined with oxaliplatin on advanced colorectal cancer. Methods Twenty patients with advanced colorectal cancer were treated with oxaliplatin 130mg/m2 intravenously once per week and capecitabine 1000mg/m2 orally twice daily for 14 days. Every 3 weeks was a treatment cycle. The effect was evaluated after two treatment cycles. Result Among 20 patients treated with oxaliplatin and capecitabine, complete response was 1 case and partial response was 7 eases. The total effective rate was 40.0%. Adverse effects were mainly grade Ⅰ～Ⅱ that includes marrow inhibitory, nausea and vomiting, diarrhea, mouth ulcer, peripheral neuritis and hand-foot syndrome. There was no serious chemo-therapy-related adverse effect. Conclusion The combined chemotherapy with oxaliplatin and capecitabine is an effective and better tolerance in treatment of advanced colorectal cancer and well worth clinical application.