CAJ | 학술논문

为阐明脊髓背角神经元痛放电的年龄相关的动力学变化,本研究采用非线性预报方法,对两组不同年龄大鼠(成年青龄鼠3～4月龄,老年鼠＞22月龄)组织损伤诱发的脊髓背角神经元痛放电峰峰间期序列进行了确定性行为的定量分析.结果显示,皮下注入蜜蜂毒,在两组大鼠均诱发脊髓背角广动力域神经元长时程放电,而老龄大鼠的痛放电峰峰间期序列表现出更高的可确定性.本研究表明,单个神经元的痛放电动力学在整个生命过程中并不是恒定不变的,伤害性神经元活动的年龄相关动力学变化可能是老年人群中多样化痛反应的内在机制之一.
위천명척수배각신경원통방전적년령상관적동역학변화,본연구채용비선성예보방법,대량조불동년령대서(성년청령서3～4월령,노년서＞22월령)조직손상유발적척수배각신경원통방전봉봉간기서렬진행료학정성행위적정량분석.결과현시,피하주입밀봉독,재량조대서균유발척수배각엄동력역신경원장시정방전,이노령대서적통방전봉봉간기서렬표현출경고적가학정성.본연구표명,단개신경원적통방전동역학재정개생명과정중병불시항정불변적,상해성신경원활동적년령상관동역학변화가능시노년인군중다양화통반응적내재궤제지일.
To demonstrate the age-related changes in the dynamics of the nociceptive discharge of dorsal horn nociceptive neurons, the nonlinear prediction method was used to quantify the degree of deterministic behavior within the interspike interval series of tissue injuryinduced firing of spinal nociceptive neurons in anesthetized adult young (3～4 months) and aged (＞22 months) rats. Subcutaneous bee venom injection induced long-term discharge of spinal wide dynamic range (WDR) neurons in both groups. However, the nociceptive discharge of single WDR neurons in the aged group showed higher determinism when compared with the adult young rats. This result suggests that the dynamics of single nocicepfive neurons may not remain constant throughout the life span, and this age-associated change may be an underlying mechanism for various pain manifestations in the elderly population.