CAJ | 학술논문

目的通过钙离子传感针在体检测阴茎海绵体平滑肌细胞外的钙离子浓度,探讨其与勃起功能障碍(ED)的相关性.方法 40只雄性SD大鼠随机分为损伤组(20只)和对照组(20只),通过剪断双侧海绵体神经制作神经性ED模型,1个月后应用钙离子传感针在体检测大鼠阴茎海绵体平滑肌细胞外的钙离子浓度,比较两组间钙离子浓度的差异.结果损伤组(ED组)钙离子浓度(电位)为(-0.31±0.35)mV,对照组钙离子浓度(电位)为(0.17±0.34)mV,两组钙离子浓度差异具统计学意义(P<0.05).结论钙离子传感针可以作为ED在体检测的一种新方法.
목적 통과개리자전감침재체검측음경해면체평활기세포외적개리자농도,탐토기여발기공능장애(ED)적상관성.방법 40지웅성SD대서수궤분위손상조(20지)화대조조(20지),통과전단쌍측해면체신경제작신경성ED모형,1개월후응용개리자전감침재체검측대서음경해면체평활기세포외적개리자농도,비교량조간개리자농도적차이.결과 손상조(ED조)개리자농도(전위)위(-0.31±0.35)mV,대조조개리자농도(전위)위(0.17±0.34)mV,량조개리자농도차이구통계학의의(P<0.05).결론 개리자전감침가이작위ED재체검측적일충신방법.
Objectives To detect the extracellular calcium concentration of corpus cavemosum smooth muscle in vivo using needle-type calcium sensor, and discuss its correlation with erctile dysfunction. Methods A total of 40 experimental SD rats were randomized into the injury group (20) and the control group (20), bilateral cavernous nerves were cut in the injury group, and nothing was done in the control group. One month later, Extracellular calcium concentration of corpus cavernosum smooth muscle was detected by needle-type calcium sensor in vivo and the results were compared between the two groups. Data was expressed as mean±SD. Results The extracellular calcium concentration was much lower in the injury group (0.17±0.34)mV than that of the control group(-0.31±0.35)mV. There was significant difference in calcium concentration of corpus cavemosum between the injury group and the control group (P<0.05). Conclusion Needle-type calcium sensor might be a new technique in evaluating erectile dysfunction.