中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
24期
3315-3317
,共3页
高血压,原发性%肾素-血管紧张素系统%血管紧张素Ⅱ%氨基肽酶A
高血壓,原髮性%腎素-血管緊張素繫統%血管緊張素Ⅱ%氨基肽酶A
고혈압,원발성%신소-혈관긴장소계통%혈관긴장소Ⅱ%안기태매A
Essential hypertension%Renin-angiotensin system%Angiotensin Ⅱ%Aminopeptidase A
目的 探讨高血压人群血浆氨基肽酶A(APA)与原发性高血压的相关性.方法 对淮南市汉族人群进行问卷调查和血压、身高、体质量的测量,征集到高血压家系的高血压患者与血压正常者分别为131例与134例、非高血压家系的高血压患者与血压正常者分别为127例与132例为研究对象.分别应用RIA法和ELISA法测定研究对象的血浆血管紧张素Ⅱ(AngⅡ)与APA水平.结果 两个家系中高血压组AngⅡ与APA水平显著高于非高血压组(t=10.3398,6.5613,11.7089,6.6683,均P＜0.01).且高血压家系高血压组AngⅡ与APA水平显著高于非高血压家系的高血压组(t=3.6201,6.1091,均P＜0.01).平均动脉血压与两个家系中高血压组AngⅡ水平与APA水平均呈显著正相关(非高血压家系r=0.315,0.392,均P＜0.05,高血压家系r=0.412,0.505,均P＜0.01).高血压家系中高血压组血浆AngⅡ水平与APA水平呈正相关(r=0.322,P＜0.05).结论 血浆APA水平在不同家系存在差异；高血压家系的高血压人群血浆APA水平显著升高,并与血压有一定的相关性.
目的 探討高血壓人群血漿氨基肽酶A(APA)與原髮性高血壓的相關性.方法 對淮南市漢族人群進行問捲調查和血壓、身高、體質量的測量,徵集到高血壓傢繫的高血壓患者與血壓正常者分彆為131例與134例、非高血壓傢繫的高血壓患者與血壓正常者分彆為127例與132例為研究對象.分彆應用RIA法和ELISA法測定研究對象的血漿血管緊張素Ⅱ(AngⅡ)與APA水平.結果 兩箇傢繫中高血壓組AngⅡ與APA水平顯著高于非高血壓組(t=10.3398,6.5613,11.7089,6.6683,均P＜0.01).且高血壓傢繫高血壓組AngⅡ與APA水平顯著高于非高血壓傢繫的高血壓組(t=3.6201,6.1091,均P＜0.01).平均動脈血壓與兩箇傢繫中高血壓組AngⅡ水平與APA水平均呈顯著正相關(非高血壓傢繫r=0.315,0.392,均P＜0.05,高血壓傢繫r=0.412,0.505,均P＜0.01).高血壓傢繫中高血壓組血漿AngⅡ水平與APA水平呈正相關(r=0.322,P＜0.05).結論 血漿APA水平在不同傢繫存在差異；高血壓傢繫的高血壓人群血漿APA水平顯著升高,併與血壓有一定的相關性.
목적 탐토고혈압인군혈장안기태매A(APA)여원발성고혈압적상관성.방법 대회남시한족인군진행문권조사화혈압、신고、체질량적측량,정집도고혈압가계적고혈압환자여혈압정상자분별위131례여134례、비고혈압가계적고혈압환자여혈압정상자분별위127례여132례위연구대상.분별응용RIA법화ELISA법측정연구대상적혈장혈관긴장소Ⅱ(AngⅡ)여APA수평.결과 량개가계중고혈압조AngⅡ여APA수평현저고우비고혈압조(t=10.3398,6.5613,11.7089,6.6683,균P＜0.01).차고혈압가계고혈압조AngⅡ여APA수평현저고우비고혈압가계적고혈압조(t=3.6201,6.1091,균P＜0.01).평균동맥혈압여량개가계중고혈압조AngⅡ수평여APA수평균정현저정상관(비고혈압가계r=0.315,0.392,균P＜0.05,고혈압가계r=0.412,0.505,균P＜0.01).고혈압가계중고혈압조혈장AngⅡ수평여APA수평정정상관(r=0.322,P＜0.05).결론 혈장APA수평재불동가계존재차이；고혈압가계적고혈압인군혈장APA수평현저승고,병여혈압유일정적상관성.
Objective To study the correlation between essential hypertension and plasma aminopeptidase A.Methods The people of the Han nationality in Huainan city received questionnaire investigation and their blood pressure,height and weight were measured.131 individuals suffered from hypertension and 134 healthy individuals belongs to hypertensive pedigree and 127 individuals suffered from hypertension and 132 healthy individuals belongs to non-hypertensive pedigree were reseached.The level of Ang Ⅱ in plasma was detected by RIA,and the level of APA was detected by ELISA.Results The levels of Ang Ⅱ and APA in plasma in HP group was significantly higher than that in NHP group in two pedigrees ( t =10.3398,6.5613,11.7089,6.6683,all P ＜ 0.01 ).Furthermore,the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree was significantly higher than that in HP group in nonhypertensive pedigree(t =3.6201,6.1091,all P ＜ 0.01 ).There was significantly positive correlation between MAP and the levels of Ang Ⅱ and APA in plasma in HP group in two pedigrees ( r =0.315,0.392,all P ＜ 0.05 in non-hypertensive pedigree,and r =0.412,0.505,all P ＜ 0.01 in hypertensive pedigree ).There was positive correlation between the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree ( r =0.322,P ＜ 0.05 ).Conclusion There was significant difference between hypertensive pedigree and non-hypertensive pedigree in the levels of APA;The levels of APA in plasma in HP group was significantly increased in the individuals suffered from hypertension,and was positively correlated with MAP.
