CAJ | 학술논문

神经肽P物质(SP)是速激肽家族的重要成员,通过与其受体相结合发挥生物学作用.P物质和其偏嗜性受体神经激肽受体-1(NK1R)广泛分布在中枢和外周神经系统及周围组织,SP通过与G蛋白耦联的受体相互作用调控多种功能.目前在mRNA水平和蛋白水平所发现的人NK1R只有两种:由5个外显子组成全长型受体(NKIR-FL)和C-末端缺乏96个氨基酸残基的截短型受体(NK1R-Tr),SP通过与NK1R-Tr或NK1R-FL的相互作用在中枢和外周神经系统及周围组织产生不同的生物学效应.
신경태P물질(SP)시속격태가족적중요성원,통과여기수체상결합발휘생물학작용.P물질화기편기성수체신경격태수체-1(NK1R)엄범분포재중추화외주신경계통급주위조직,SP통과여G단백우련적수체상호작용조공다충공능.목전재mRNA수평화단백수평소발현적인NK1R지유량충:유5개외현자조성전장형수체(NKIR-FL)화C-말단결핍96개안기산잔기적절단형수체(NK1R-Tr),SP통과여NK1R-Tr혹NK1R-FL적상호작용재중추화외주신경계통급주위조직산생불동적생물학효응.
The neuropeptide substance P (SP) is an important member of the tachykinin receptor family , it exert its biological action through transmembrane G-protein coupled receptors. SP and its preferential ligands neurokinin-1 receptor (NK1R) are abundantly expressed in central and peripheral nervous system. Neuropeptides, including Tachykinins are molecular messengers that regulate multiple functions in the central and periphery nervons systems via G-protein-coupled receptors. Two naturally occurring NK1R a ' classic' fulllength receptor (NK1R-FL) and a truncated (NK1R-Tr) mediate the effects of SP. The human NK1R gene is divided into five exons, allowing the generation of multiple splice variants. The only splice variant identified in human tissues at mRNA and protein level is the isoform which lacks 96 amino acid residues at the C-terminus.SP exerts different effect by coupling NK1R-FL and NK1R-Tr on central and peripheral nervous system.