中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
3期
341-342
,共2页
血液滤过%烧伤%肾功能衰竭,急性%白细胞介素6
血液濾過%燒傷%腎功能衰竭,急性%白細胞介素6
혈액려과%소상%신공능쇠갈,급성%백세포개소6
Hemofiltration%Burn%Kidney failure,acute%Interleukin-6
目的 探讨连续性血液净化(CBP)治疗重度烧伤并发急性肾功能衰竭的疗效及安全性.方法 对12例严重烧伤并发急性肾功能衰竭患者早期接受CBP治疗,观察患者治疗前后生命体征、肾功能、血电解质及白细胞介素-6(IL-6)水平的变化.结果 12例患者治疗后,肌酐、血钠、血钾浓度明显下降[(376.2±24.5)与(145.2±57.1)μmol/L、(5.3±1.6)与(4.0±0.7)mmol/L、(153.4±13.0)与(140.1±8.6)mmol/L](t=2.79、3.06、3.01,均P＜0.05),临床症状明显改善(均P＜0.05);治疗前APACHEⅡ评分及IL-6水平分别为:(15.2±5.8)分、(264.31±122.42)ng/L,治疗后分别为:(5.4±3.6)分、(94.18±63.82)ng/L,治疗前后差异均有统计学意义(t=4.17、3.67,均P＜0.05);治愈8例,死亡4例.结论 CBP能清除烧伤并发急性肾功能衰竭患者血循环中的炎性介质,维持内环境的稳定,是一种有效的辅助治疗方法.
目的 探討連續性血液淨化(CBP)治療重度燒傷併髮急性腎功能衰竭的療效及安全性.方法 對12例嚴重燒傷併髮急性腎功能衰竭患者早期接受CBP治療,觀察患者治療前後生命體徵、腎功能、血電解質及白細胞介素-6(IL-6)水平的變化.結果 12例患者治療後,肌酐、血鈉、血鉀濃度明顯下降[(376.2±24.5)與(145.2±57.1)μmol/L、(5.3±1.6)與(4.0±0.7)mmol/L、(153.4±13.0)與(140.1±8.6)mmol/L](t=2.79、3.06、3.01,均P＜0.05),臨床癥狀明顯改善(均P＜0.05);治療前APACHEⅡ評分及IL-6水平分彆為:(15.2±5.8)分、(264.31±122.42)ng/L,治療後分彆為:(5.4±3.6)分、(94.18±63.82)ng/L,治療前後差異均有統計學意義(t=4.17、3.67,均P＜0.05);治愈8例,死亡4例.結論 CBP能清除燒傷併髮急性腎功能衰竭患者血循環中的炎性介質,維持內環境的穩定,是一種有效的輔助治療方法.
목적 탐토련속성혈액정화(CBP)치료중도소상병발급성신공능쇠갈적료효급안전성.방법 대12례엄중소상병발급성신공능쇠갈환자조기접수CBP치료,관찰환자치료전후생명체정、신공능、혈전해질급백세포개소-6(IL-6)수평적변화.결과 12례환자치료후,기항、혈납、혈갑농도명현하강[(376.2±24.5)여(145.2±57.1)μmol/L、(5.3±1.6)여(4.0±0.7)mmol/L、(153.4±13.0)여(140.1±8.6)mmol/L](t=2.79、3.06、3.01,균P＜0.05),림상증상명현개선(균P＜0.05);치료전APACHEⅡ평분급IL-6수평분별위:(15.2±5.8)분、(264.31±122.42)ng/L,치료후분별위:(5.4±3.6)분、(94.18±63.82)ng/L,치료전후차이균유통계학의의(t=4.17、3.67,균P＜0.05);치유8례,사망4례.결론 CBP능청제소상병발급성신공능쇠갈환자혈순배중적염성개질,유지내배경적은정,시일충유효적보조치료방법.
Objective To investigate the changes in severe burn patients with acute renal failure by using continuous blood purification(CBP). Methods Twelve severe bum patients underwent early CBP were included in this study. The levels of creatinine、blood urea nitrogen and interleukin-6(IL-6) in plasma were determined. The termperature and heart were also observed. Results After the treatment of CBP,the clinical symptoms were improved obviously ( P ＜ 0. 05 ). The levels of creatinine[( 376. 2 ± 24. 5 ) μ mol/L vs ( 145.2 ± 57. 1 ) μmol/L] 、sodium concentration [( 5.3 ± 1.6 ) mmol/L vs ( 4. 0 ± 0. 7 ) mmol/L] and potassium concentration [( 153. 4 ± 13.0 ) mmol/L vs( 140. 1 ±8.6)mmol/L]in plasma were all decreased evidently after the treatment of CBP. There were significant differences ( t = 2. 79,3.06,3. 01, P ＜ 0. 05 ). The levels of IL-6 and APACHE Ⅱ score were ( 264. 31 ± 122.42 ) ng/Land( 15.2 ±5.8) scores before treatment. While after treatment,their levels were(94. 18 ±63. 82) ng/L and(5.4 ±3. 6) scores. The difference was also significant ( t = 4. 17,3. 67, P ＜ 0. 05 ). In this study, 8 patients cured and 4 patients died. Conclusion CBP could eliminate inflammation factors effectively in severe burn patients with acute renal failure. It could afford a useful assist treatment to these patients.
