CAJ | 학술논문

2003年至2006年在我院门诊、住院及所管辖社区的560例原发性高血压患者分为2组:福辛普利组260例(10～20 mg,1次/d),苯磺酸氨氯地平组300例(5～10 mg,1次/d),2组疗程均为12个月.分别在给药前及给药后6个月、12个月采用VP-1000全自动动脉硬化检测仪进行四肢血压、脉搏波速度(baPWV)的检查.结果示服药后福辛普利组平均血压(136/85 mm Hg,1 mm Hg=0.133 kPa)高于苯磺酸氨氯地平组(132/76 mm Hg);福辛普利组平均baPWV(1310 cm/s)小于苯磺酸氨氯地平组(1400 cm1/s);福辛普利组平均咏压、(52 mm Hg)小于苯磺酸氨氯地平组(56 mm Hg).均P＜0.01.提示苯磺酸氨氯地平降压幅度大于福辛普利,福辛普利对大动脉弹性的改善强于苯磺酸氨氯地平.
2003년지2006년재아원문진、주원급소관할사구적560례원발성고혈압환자분위2조:복신보리조260례(10～20 mg,1차/d),분광산안록지평조300례(5～10 mg,1차/d),2조료정균위12개월.분별재급약전급급약후6개월、12개월채용VP-1000전자동동맥경화검측의진행사지혈압、맥박파속도(baPWV)적검사.결과 시복약후복신보리조평균혈압(136/85 mm Hg,1 mm Hg=0.133 kPa)고우분광산안록지평조(132/76 mm Hg);복신보리조평균baPWV(1310 cm/s)소우분광산안록지평조(1400 cm1/s);복신보리조평균영압、(52 mm Hg)소우분광산안록지평조(56 mm Hg).균P＜0.01.제시분광산안록지평강압폭도대우복신보리,복신보리대대동맥탄성적개선강우분광산안록지평.
A total of 560 patients with primary hypertension were divided into two groups.Of them,260 were treated with Fosinopril(10～20 mg once daily),and the other 300 were treated with Amlodipine (5～10 mg once daily).The treatment lasted for 12 months in both groups.The levels of blood pressure (BP)、braehial ankle pulse wave velocity(baPWV)and pulse pressure(PP)were examined at baseline,6 month and 12 month with automatic analysis system of arteriosclerosis.BP in Amlodipine group(132/76 mm Hg)decreased more significantly than Fosinopril group(136/85 mm Hg),but Fosinopril group showed more remarkable changes in baPWV(1310 cm/s)and PP(52 mm Hg)than Amlodipine group(1400 cm/s and 56 mm Hg).