CAJ | 학술논문

目的明确Peroxiredoxin 6(Prx6)在胃癌中的表达及其临床意义.方法选择1992至2000年北京大学临床肿瘤学院、北京大学第一医院及内蒙古医学院的胃癌病例手术切除后的石蜡包埋组织,其中胃癌86例,癌旁形态学正常组织69例,通过查阅病理档案获取其临床病理资料；用组织微阵列和免疫组织化学染色方法检测组织中Prx6蛋白表达水平.结果 Prx6以细胞质着色为主,胃癌组织中28例(32.6％)表达阳性；癌旁形态学正常组织中65例(94.2％)表达阳性(P＜0.01).在53例高中分化胃癌组织中,21例( 39.6％) Prx6高表达；在33例低分化胃癌组织中,2例(6.1％)Prx6高表达.Prx6在胃癌组织中的表达与患者的年龄、性别、病变部位、浸润深度、临床分期、血管浸润及肝转移均无明显相关性(均P ＞0.05).结论 Prx6在胃癌组织中的表达低于癌旁组织,表达强弱与胃癌组织的分化程度有关.
목적 명학Peroxiredoxin 6(Prx6)재위암중적표체급기림상의의.방법 선택1992지2000년북경대학림상종류학원、북경대학제일의원급내몽고의학원적위암병례수술절제후적석사포매조직,기중위암86례,암방형태학정상조직69례,통과사열병리당안획취기림상병리자료；용조직미진렬화면역조직화학염색방법검측조직중Prx6단백표체수평.결과 Prx6이세포질착색위주,위암조직중28례(32.6％)표체양성；암방형태학정상조직중65례(94.2％)표체양성(P＜0.01).재53례고중분화위암조직중,21례( 39.6％) Prx6고표체；재33례저분화위암조직중,2례(6.1％)Prx6고표체.Prx6재위암조직중적표체여환자적년령、성별、병변부위、침윤심도、림상분기、혈관침윤급간전이균무명현상관성(균P ＞0.05).결론 Prx6재위암조직중적표체저우암방조직,표체강약여위암조직적분화정도유관.
Objective To elucidate the significance of anti-oxidant protein peroxiredoxin 6 (Prx6) expression in gastric cancer (GC) tissue.Methods Eighty-six GC tissues and 69 para-cancer tissues from surgically resected specimens were included. And the clinico-pathological data were collected by reviewing medical records. Tissue microarray and immunohistochemistry (IHC) were used to detect Prx6 protein expression in tissues.Results Prx6 protein was predominantly expressed in cytoplasm.Its expression rate in GC tissues (32.6％,n =28) was significantly lower than that in para-cancer normal tissues (94.2％,n =65,P ＜ 0.05). And its protein overexpression rate in well and moderately-differentiated GC tissues was significantly higher than that in lowly-differentiated ones (39.6％ (21/53) vs 6.1％ (2/33),P ＜0.05).Prx6 expression in gastric cancer tissues was not significantly related to age and sex of patients,lesion site,depth of invasion,clinical staging,vascular invasion and liver metastasis.Conclusions The level of Prx6 protein is lower in GC tissues than that in normal para-cancer ones.And it is significantly correlated with the differentiation degree of GC.