临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2009年
16期
1409-1411
,共3页
格林-巴利综合征%丙种球蛋白%治疗
格林-巴利綜閤徵%丙種毬蛋白%治療
격림-파리종합정%병충구단백%치료
Guillian-Barre syndrome%human gamma globulin%therapy
目的 观察静脉滴注不同剂量丙种球蛋白治疗吉兰一巴雷综合征的临床疗效.方法 123倒吉兰一巴雷患者分成3组:低剂量丙种球蛋白组(0.2 g·kg-1·d-1)、大剂量丙种球蛋白组(0.4 g·kg-1·d-1)和单独应用糖皮质激素治疗组,记录其临床症状的改善状况,并进行比较.结果 低剂量和大剂量丙种球蛋白对于轻度和中度的格林一巴利患者效果好于激素组(P分别为0.004,0.008,0.012,0.022),且不良反应少,对重度患者疗效差异无统计学意义(P=0.788).低剂量和大剂量两组患者在临床疗效上没有区别.结论 丙种球蛋白治疗效果明显好于激素组,且低剂量和大剂量组差异无统计学意义.
目的 觀察靜脈滴註不同劑量丙種毬蛋白治療吉蘭一巴雷綜閤徵的臨床療效.方法 123倒吉蘭一巴雷患者分成3組:低劑量丙種毬蛋白組(0.2 g·kg-1·d-1)、大劑量丙種毬蛋白組(0.4 g·kg-1·d-1)和單獨應用糖皮質激素治療組,記錄其臨床癥狀的改善狀況,併進行比較.結果 低劑量和大劑量丙種毬蛋白對于輕度和中度的格林一巴利患者效果好于激素組(P分彆為0.004,0.008,0.012,0.022),且不良反應少,對重度患者療效差異無統計學意義(P=0.788).低劑量和大劑量兩組患者在臨床療效上沒有區彆.結論 丙種毬蛋白治療效果明顯好于激素組,且低劑量和大劑量組差異無統計學意義.
목적 관찰정맥적주불동제량병충구단백치료길란일파뢰종합정적림상료효.방법 123도길란일파뢰환자분성3조:저제량병충구단백조(0.2 g·kg-1·d-1)、대제량병충구단백조(0.4 g·kg-1·d-1)화단독응용당피질격소치료조,기록기림상증상적개선상황,병진행비교.결과 저제량화대제량병충구단백대우경도화중도적격림일파리환자효과호우격소조(P분별위0.004,0.008,0.012,0.022),차불량반응소,대중도환자료효차이무통계학의의(P=0.788).저제량화대제량량조환자재림상료효상몰유구별.결론 병충구단백치료효과명현호우격소조,차저제량화대제량조차이무통계학의의.
Objective To observe the therapy effect of low dose and high dose human gamma globulin for acute Guillian-Barre syndrome. Methods The patients with acute Guillian-Barre syndrome were divided into three groups Improvements of clinical symptoms of human gamma globulin were better than those of glucocorticosteroid group in mild and medium Guillian-Barre syndrome(P = 0.004,0. 008,0. 012,0. 022, respetively), side effects were less seen. There were no significant differences in these measures in severe Guillian-Barre syndrome(P = 0. 788). Conclusion The cure effect of human gamma globulin is better than that of glucoeorticosteroid. There is no significant difference between low dose and high dose human gamma globulin for acute Guillian-Barre syndrome.
