国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2009年
6期
429-432
,共4页
胃癌%HIF-1α%VEGF%肿瘤转移
胃癌%HIF-1α%VEGF%腫瘤轉移
위암%HIF-1α%VEGF%종류전이
Gastric carcinoma%HIF-1α (hypoxia-inducible factor-1)%VEGF (vascular endothelial growth factor)%Tumor metastasis
目的 通过对不同分化和高低转移的胃癌组织中HIF-1α和VEGF表达情况的检测,揭示HIF-1α和VEGF与胃癌恶化程度及转移的关系.方法 用免疫组织化学法(SP法)检测HIF-1α和VEGF在胃癌组织中的表达.结果 HIF-1α和VEGF的表达均高于正常组织.HIF-1α和VEGF在胃癌中的表达与分化、转移相关.HIF-1α和VEGF在胃癌中的表达是正相关.结论 HIF-1α和VEGF与胃癌的分化、转移密切相关.HIF-1α与VEGF在胃癌中的表达密切正相关.两种因子高表达提示预后不良,具有一定的临床诊断意义.
目的 通過對不同分化和高低轉移的胃癌組織中HIF-1α和VEGF錶達情況的檢測,揭示HIF-1α和VEGF與胃癌噁化程度及轉移的關繫.方法 用免疫組織化學法(SP法)檢測HIF-1α和VEGF在胃癌組織中的錶達.結果 HIF-1α和VEGF的錶達均高于正常組織.HIF-1α和VEGF在胃癌中的錶達與分化、轉移相關.HIF-1α和VEGF在胃癌中的錶達是正相關.結論 HIF-1α和VEGF與胃癌的分化、轉移密切相關.HIF-1α與VEGF在胃癌中的錶達密切正相關.兩種因子高錶達提示預後不良,具有一定的臨床診斷意義.
목적 통과대불동분화화고저전이적위암조직중HIF-1α화VEGF표체정황적검측,게시HIF-1α화VEGF여위암악화정도급전이적관계.방법 용면역조직화학법(SP법)검측HIF-1α화VEGF재위암조직중적표체.결과 HIF-1α화VEGF적표체균고우정상조직.HIF-1α화VEGF재위암중적표체여분화、전이상관.HIF-1α화VEGF재위암중적표체시정상관.결론 HIF-1α화VEGF여위암적분화、전이밀절상관.HIF-1α여VEGF재위암중적표체밀절정상관.량충인자고표체제시예후불량,구유일정적림상진단의의.
Objective To determin the expression levels of HIF-1α and vascular endothelial growth factor (VEGF) in gastric carcinoma tissue and ascertaining whether HIF-1α and VEGF play important roles in tumor malignant progression and metastasis.Methods HIF-1α and VEGF protein were detected in gastric carcinoma tissue by immunohistochemistry using streptavidin/peroxidase (SP).Results HIF-1α and VEGF were mainly expressed higer than normal ones.The positive expression of HIF-1α and VEGF were correlated with malignant progression and metastasis.There was a pnsitive correlation between expression of HIF-1α and VEGF.Conclu-sion The expression of HIF-1α and VEGF may play an important role in the development of gastric carcino-ma.The expression of HIF-1α is significantly correlated with malignant progression and metastasis.HIF-1α and VEGF are combinated to advanced tumor progression.The expression of these two factors suggest bad prognosis.
