CAJ | 학술논문

过氧化氢酶(catalase,CAT)是人体内很重要的一种抗氧化酶,它与超氧化物歧化酶(superoxide dismutase,SOD),谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)共同构成人体重要的抗氧化酶系统,三者协同,减少了活性氧自由基的产生,防止脂质过氧化及其中间代谢产物对机体的损害,维持体内氧化-抗氧化平衡.过氧化氢酶的基因多态性可能与该酶的活性及转录活性有关,从而影响个体间对疾病的易感性不同.
과양화경매(catalase,CAT)시인체내흔중요적일충항양화매,타여초양화물기화매(superoxide dismutase,SOD),곡광감태과양화물매(glutathione peroxidase,GSH-Px)공동구성인체중요적항양화매계통,삼자협동,감소료활성양자유기적산생,방지지질과양화급기중간대사산물대궤체적손해,유지체내양화-항양화평형.과양화경매적기인다태성가능여해매적활성급전록활성유관,종이영향개체간대질병적역감성불동.
Catalase is one of three enzymes within the important huamn antioxidant enzyme system, which also includes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). They coordinate to reduce the production of active oxygen free radicals , to prevent lipid peroxidation and its intermediate metabolites from damaging human body, and to maintain oxidative-antioxidative balance. Catalase gene polymorphisms,and its haplotypes may be related to enzyme activity and transcriptional activity, and thus affect the sensitivity to some human diseases in different individuals. The study reviewed the structure and function of catalase, and gene polymorphism and its association with human diseases.