CAJ | 학술논문

目的探讨毛霉病的临床表现、预后和病理表现之间可能存在的关系.方法回顾性分析1989-2006年我院诊治的7例经真菌培养证实为毛霉病患者的临床资料和病理切片.结果 7例中鼻脑毛霉病1例、皮肤毛霉病6例,其中2例为毛霉性坏死性筋膜炎.鼻脑毛霉病和毛霉性坏死性筋膜炎患者病情进展快,均以死亡告终;其皮损组织病理表现呈混合性炎症细胞浸润,坏死明显,可见大量菌丝和侵血管现象.4例以浸润性红斑为主要表现的皮肤毛霉病患者病情进展慢,有2例已治愈;其皮损组织病理呈肉芽肿性炎症,菌丝较少,未见明显的侵血管现象.7例均未见明确的菌丝侵神经现象.结论毛霉病皮损组织病理表现呈混合性炎症细胞浸润,菌丝多,出现明显侵血管现象者预后较差.
목적 탐토모매병적림상표현、예후화병리표현지간가능존재적관계.방법 회고성분석1989-2006년아원진치적7례경진균배양증실위모매병환자적림상자료화병리절편.결과 7례중비뇌모매병1례、피부모매병6례,기중2례위모매성배사성근막염.비뇌모매병화모매성배사성근막염환자병정진전쾌,균이사망고종;기피손조직병리표현정혼합성염증세포침윤,배사명현,가견대량균사화침혈관현상.4례이침윤성홍반위주요표현적피부모매병환자병정진전만,유2례이치유;기피손조직병리정육아종성염증,균사교소,미견명현적침혈관현상.7례균미견명학적균사침신경현상.결론 모매병피손조직병리표현정혼합성염증세포침윤,균사다,출현명현침혈관현상자예후교차.
Objective To investigate the relationship between the clinical manifestations,prognosis and histopathological findings of mucormycosis.Methods The clinical data on and pathological findings from 7 cases of mucormycosis confirmed by fungal culture in the institute from 1989 to 2006 were analyzed retrospectively.Results There was 1 case of hinocerebral mucormycosis and 6 cases of cutaneous mucormycosis,among them,2 were mucormycotic necrotizing fasciitis (MNF).The condition of patients with rhinocerebral mucormycosis or MNF aggravated rapidly and all the 3 patients died from mucormycosis. Histopathological examination showed mixed infiltrates of inflammatory cells as well as necrosis and angioin vasion.On the contrary,the condition of the remaining 4 patients with cutanesus mucormycosis,who presented mainly with indurated erythematous patch,progressed slowly,and 2 patients were cured.Histologically,the lesions were characterized by granulbmatous infiltration with a few hyphae;no typical angioinva sion phenomenon was noted.There was no evidence of perineural invasion with hyphae in any of the 7 cases.Conclusion In patients with mucormycosis,histopathological findings characterized by mixed infiltrates of inflammatory cells,numerous hyphae and typical angioinvasion phenomenon may herald a poor prognosis.