CAJ | 학술논문

目的探讨新疆维吾尔族胶质瘤患者肿瘤组织中血管内皮生长因子(VEGF)表达水平与肿瘤病理级别之间的相关性以及民族因素对胶质瘤VEGF表达水平的影响.方法运用免疫组化法检测33例维吾尔族胶质瘤患者以及61例汉族胶质瘤患者肿瘤组织中的VEGF表达水平,对其与病理级别之间的相关性和种族因素对胶质瘤肿瘤组织中VEGF表达水平的影响进行分析.结果 61例汉族胶质瘤患者肿瘤VEGF阳性率为81.97％,33例维族胶质瘤患者VEGF阳性率为60.61％,两个种族间差异有统计学意义(P＜0.05).分别对两民族胶质瘤组织VEGF表达水平与病理级别的相关性进行统计学分析,汉族患者肿瘤VEGF表达水平与病理级别显著相关(P＜0.05)；维吾尔族患者肿瘤VEGF表达水平与病理级别无明显相关(P＞0.05).结论胶质瘤患者肿瘤组织VEGF阳性率及其表达水平与病理级别之间的相关性均受到种族因素的影响.
목적 탐토신강유오이족효질류환자종류조직중혈관내피생장인자(VEGF)표체수평여종류병리급별지간적상관성이급민족인소대효질류VEGF표체수평적영향.방법 운용면역조화법검측33례유오이족효질류환자이급61례한족효질류환자종류조직중적VEGF표체수평,대기여병리급별지간적상관성화충족인소대효질류종류조직중VEGF표체수평적영향진행분석.결과 61례한족효질류환자종류VEGF양성솔위81.97％,33례유족효질류환자VEGF양성솔위60.61％,량개충족간차이유통계학의의(P＜0.05).분별대량민족효질류조직VEGF표체수평여병리급별적상관성진행통계학분석,한족환자종류VEGF표체수평여병리급별현저상관(P＜0.05)；유오이족환자종류VEGF표체수평여병리급별무명현상관(P＞0.05).결론 효질류환자종류조직VEGF양성솔급기표체수평여병리급별지간적상관성균수도충족인소적영향.
Objective To investigate the correlation between the expression of tumor VEGF and pathological grade,and the influence of racial factors on tumor VEGF expression levels for glioma patients.Methods Compare and analysis the correlation between the pathological grade and VEGF levels and the racial factors on VEGF expression levels by the immunohistochemical staining on the tumor specimens of 33 Uygur and 61Han.Results The positive rate of 61Han gliomas pations with VEGF is 81.97％ and 33 cases of the Uygur is 60.61％,there's clear correlation between the racial factors and the tumor VEGF levels.(P ＜ 0.05).Comparative the two groups patients separately with pathological level and tumor VEGF level,there is no clear correlation in Uygu ( P ＞ 0.05 ) and opposite in Han( P ＜ 0.05 ).Conclusion There's significant effect of the racial factors on the positive of glioma's VEGF and the relation between the pathological grade and the expression levels.