无机化学学报
無機化學學報
무궤화학학보
JOURNAL OF INORGANIC CHEMISTRY
2011年
3期
565-570
,共6页
张金超%王立伟%李路伟%张芳芳%马丽丽%李小六
張金超%王立偉%李路偉%張芳芳%馬麗麗%李小六
장금초%왕립위%리로위%장방방%마려려%리소륙
N-酰化-L-缬氨酸双阴离子%钯(Ⅱ)配合物%单晶结构%抗肿瘤活性
N-酰化-L-纈氨痠雙陰離子%鈀(Ⅱ)配閤物%單晶結構%抗腫瘤活性
N-선화-L-힐안산쌍음리자%파(Ⅱ)배합물%단정결구%항종류활성
N-acylated-L-valine dianion%Pd(Ⅱ) complexe%crystal structure%cytotoxicity
本文首次报道了2个钯(Ⅱ)的配合物[Pd(bipy)(4-CH3Bzval-N,O)](1)和[Pd(phen)(4-CH3Bzval-N,O)](2)(bipy=2,2'-联吡啶,phen=1,10-菲咯啉,4-CH3Bzval-N,O=N-(4-甲基苯甲酰)-L-缬氨酸双阴离子)的合成及晶体结构,利用MTT法和SRB法研究了配合物的体外抗肿瘤活性.配合物2属单斜晶系P21/n空间群,其中a=1.16292(8)nm,b=1.074 03(7)nm,c=1.82114(12)nm,V=2.232 8(3)nm3,Z=4.结果显示:2个配合物对HL-60,BGC-823,Bel-7402和KB 4种人的肿瘤细胞表现出一定的活性和选择性,但其活性均小于顺铂.
本文首次報道瞭2箇鈀(Ⅱ)的配閤物[Pd(bipy)(4-CH3Bzval-N,O)](1)和[Pd(phen)(4-CH3Bzval-N,O)](2)(bipy=2,2'-聯吡啶,phen=1,10-菲咯啉,4-CH3Bzval-N,O=N-(4-甲基苯甲酰)-L-纈氨痠雙陰離子)的閤成及晶體結構,利用MTT法和SRB法研究瞭配閤物的體外抗腫瘤活性.配閤物2屬單斜晶繫P21/n空間群,其中a=1.16292(8)nm,b=1.074 03(7)nm,c=1.82114(12)nm,V=2.232 8(3)nm3,Z=4.結果顯示:2箇配閤物對HL-60,BGC-823,Bel-7402和KB 4種人的腫瘤細胞錶現齣一定的活性和選擇性,但其活性均小于順鉑.
본문수차보도료2개파(Ⅱ)적배합물[Pd(bipy)(4-CH3Bzval-N,O)](1)화[Pd(phen)(4-CH3Bzval-N,O)](2)(bipy=2,2'-련필정,phen=1,10-비각람,4-CH3Bzval-N,O=N-(4-갑기분갑선)-L-힐안산쌍음리자)적합성급정체결구,이용MTT법화SRB법연구료배합물적체외항종류활성.배합물2속단사정계P21/n공간군,기중a=1.16292(8)nm,b=1.074 03(7)nm,c=1.82114(12)nm,V=2.232 8(3)nm3,Z=4.결과현시:2개배합물대HL-60,BGC-823,Bel-7402화KB 4충인적종류세포표현출일정적활성화선택성,단기활성균소우순박.
Two novel palladium(Ⅱ) complexes, [Pd(bipy)(4-CH3Bzval-N,O)] (1) and [Pd(phen)(4-CH3Bzval-N,O)] (2)(bipy =2,2' -bipyridine, phen = 1,10-phenanthroline, 4-CH3Bzval-N,O =N-(4-methylbenzoyl)-L-valine dianion)have been prepared and structurally characterized, the cytotoxicity in vitro has also been investigated by MTT and SRB assays. The complex 2 crystallizes in the hexagonal system, space group P21/n with cell parameters a=1.162 92(8) nm, b=1.074 03(7) nm, c=1.821 14(12)nm, V=2.232 8(3) nm3and Z=4. The complexes (1 and 2) presented cytotoxic effects and selectivity, but were less active than cisplatin against HL-60, BGC-823, Bel-7402 and KB cell lines.CCDC: 761046.
