CAJ | 학술논문

系统性红斑狼疮是一种复杂的慢性、全身性自身免疫性疾病,其发病机制尚不明确.近年研究表明,microRNA和DNA甲基化在内的表观遗传修饰异常可能在系统性红斑狼疮的发生发展中起作用.MicroRNA是非编码单链小RNA,已有研究提示,microRNA参与了系统性红斑狼疮的发病和疾病进展,而其与DNA甲基化的相互作用可通过调控细胞内基因表达进而影响疾病的发生发展.概述了microRNA的异常表达及其与DNA甲基化之间的相互关系在系统性红斑狼疮发病机制中的作用,旨在为系统性红斑狼疮的研究提供新的思路.
계통성홍반랑창시일충복잡적만성、전신성자신면역성질병,기발병궤제상불명학.근년연구표명,microRNA화DNA갑기화재내적표관유전수식이상가능재계통성홍반랑창적발생발전중기작용.MicroRNA시비편마단련소RNA,이유연구제시,microRNA삼여료계통성홍반랑창적발병화질병진전,이기여DNA갑기화적상호작용가통과조공세포내기인표체진이영향질병적발생발전.개술료microRNA적이상표체급기여DNA갑기화지간적상호관계재계통성홍반랑창발병궤제중적작용,지재위계통성홍반랑창적연구제공신적사로.
Systemic lupus erythematosus (SLE) is a complex,chronic and autoimmune disease with unclear pathogenesis.Recent studies have shown that abnormality in epigenetic modifications,including microRNAs and DNA methylation,may play an important role in the occurrence and development of SLE.It has been demonstrated that microRNAs,as a group of small non-coding single-stranded RNAs,take part in the occurrence and development of SLE,and their interaction with DNA methylation may affect the occurrence and development of SLE via regulating intracellular gene expression.The authors summarize the roles of abnormal expression of microRNAs as well as their interaction with DNA methylation in the pathogenesis of SLE,aiming to offer a new clue into the research in SLE.