CAJ | 학술논문

Toll样受体(TLR)是天然免疫的主要受体,促进适应性免疫.TLR不仅表达在免疫细胞上,也表达在上皮细胞和肿瘤细胞上.与内外源性配体结合后,激活胞内信号通路,释放大量炎症因子,营造炎性微环境,导致肿瘤形成、侵袭和转移.
Toll양수체(TLR)시천연면역적주요수체,촉진괄응성면역.TLR불부표체재면역세포상,야표체재상피세포화종류세포상.여내외원성배체결합후,격활포내신호통로,석방대량염증인자,영조염성미배경,도치종류형성、침습화전이.
Toll-like receptor (TLR) plays a crucial role in innate immune response and the subsequent induction of adaptive immunity. TLR is expressed on immune cells as well as epithelial cells and tumor cells. When endogenous and exogenous ligands bind with TLR, TLR signaling pathways are activated and a large number of inflammatory cytokines are released, creating an inflammatory microenvironment and leading to tumor formation, invasion and metastasis.