CAJ | 학술논문

分枝杆菌肉芽肿是由细菌与不同的宿主细胞如巨噬细胞、树突细胞、淋巴细胞等相互作用,在各种免疫分子如细胞因子、黏附分子、补体等参与下,形成的特征性病理学结构.其形成过程中细菌各种成分、宿主不同细胞、产生的不同免疫分子均起重要作用.而斑马鱼模型的建立及原位荧光观察方法的应用亦为分枝杆菌尤其是海鱼分枝杆菌感染肉芽肿的体内形成及演变研究提供基础.
분지간균육아종시유세균여불동적숙주세포여거서세포、수돌세포、림파세포등상호작용,재각충면역분자여세포인자、점부분자、보체등삼여하,형성적특정성병이학결구.기형성과정중세균각충성분、숙주불동세포、산생적불동면역분자균기중요작용.이반마어모형적건립급원위형광관찰방법적응용역위분지간균우기시해어분지간균감염육아종적체내형성급연변연구제공기출.
Mycobacterial granuloma is a specific pathogenic structure formed through the interaction between bacteria and different host cells such as macrophages,dendritic cells and lymphocytes with the involvement of various immune molecules such as cytokines,adhesion molecules,complements,etc.During the process of formation,bacteria,host cells and immune molecules each play indispensable roles.Moreover,the development of zebrafish model and application of fluorescence-based in situ observation technique have provided a basis for the investigation into the in vivo formation and evolution of mycobacterial granuloma especially Mycobacterium marinum granuloma.