中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2012年
7期
421-424
,共4页
茅李莉%肖新华%刘俊涛%宋红梅%于淼%孙晓方%张茜%李文慧%张化冰%黎明
茅李莉%肖新華%劉俊濤%宋紅梅%于淼%孫曉方%張茜%李文慧%張化冰%黎明
모리리%초신화%류준도%송홍매%우묘%손효방%장천%리문혜%장화빙%려명
瘦素%胎儿%宫内生长发育
瘦素%胎兒%宮內生長髮育
수소%태인%궁내생장발육
Leptin%Fetals%Intrauterine growth
目的 探讨瘦素在胎儿宫内生长发育中的作用,为代谢疾病的早期干预提供实验依据.方法 连续入选2009年7月至2010年1月在北京协和医院出生的单胎足月新生儿266名(男婴140名,女婴126名),留取脐带血,出生后立即测量新生儿体重、身长、头围及胎盘重量.根据出生体重将新生儿分为低出生体重组(n =58,男婴25例,女婴33例)、正常出生体重组(n=180,男婴99名,女婴81名)和高出生体重组(n =28,男婴16例,女婴12例).采用放射免疫分析法测定脐带血瘦素水平.采用独立样本t检验、Pearson相关分析、多元线性回归分析进行数据统计.结果 与正常出生体重组[(9±5)μg/L]相比,低出生体重组脐带血瘦素水平[(7±5)μg/L]明显降低(t=3.216,P＜0.05),高出生体重组[(15±7)μg/L]明显升高(t=-4.026,P＜0.01).女婴脐带血瘦素水平[(11±6) μg/L]明显高于男婴[(8±5)μg/L,t=-3.800,P＜0.0i].Pearson相关分析显示,脐带血瘦素水平与新生儿出生体重、身长、体质指数和胎盘重量呈显著正相关(r值分别为0.391、0.280、0.361、0.323,均P＜0.01).校正母亲年龄、妊娠前体质指数、新生儿性别和胎龄后,脐带血瘦素水平仍与出生体重呈直线正相关(r2 =0.289,P＜0.01).结论 脐带血瘦素水平与新生儿出生体重呈正相关,有望作为反映新生儿宫内生长发育的一个客观指标.
目的 探討瘦素在胎兒宮內生長髮育中的作用,為代謝疾病的早期榦預提供實驗依據.方法 連續入選2009年7月至2010年1月在北京協和醫院齣生的單胎足月新生兒266名(男嬰140名,女嬰126名),留取臍帶血,齣生後立即測量新生兒體重、身長、頭圍及胎盤重量.根據齣生體重將新生兒分為低齣生體重組(n =58,男嬰25例,女嬰33例)、正常齣生體重組(n=180,男嬰99名,女嬰81名)和高齣生體重組(n =28,男嬰16例,女嬰12例).採用放射免疫分析法測定臍帶血瘦素水平.採用獨立樣本t檢驗、Pearson相關分析、多元線性迴歸分析進行數據統計.結果 與正常齣生體重組[(9±5)μg/L]相比,低齣生體重組臍帶血瘦素水平[(7±5)μg/L]明顯降低(t=3.216,P＜0.05),高齣生體重組[(15±7)μg/L]明顯升高(t=-4.026,P＜0.01).女嬰臍帶血瘦素水平[(11±6) μg/L]明顯高于男嬰[(8±5)μg/L,t=-3.800,P＜0.0i].Pearson相關分析顯示,臍帶血瘦素水平與新生兒齣生體重、身長、體質指數和胎盤重量呈顯著正相關(r值分彆為0.391、0.280、0.361、0.323,均P＜0.01).校正母親年齡、妊娠前體質指數、新生兒性彆和胎齡後,臍帶血瘦素水平仍與齣生體重呈直線正相關(r2 =0.289,P＜0.01).結論 臍帶血瘦素水平與新生兒齣生體重呈正相關,有望作為反映新生兒宮內生長髮育的一箇客觀指標.
목적 탐토수소재태인궁내생장발육중적작용,위대사질병적조기간예제공실험의거.방법 련속입선2009년7월지2010년1월재북경협화의원출생적단태족월신생인266명(남영140명,녀영126명),류취제대혈,출생후립즉측량신생인체중、신장、두위급태반중량.근거출생체중장신생인분위저출생체중조(n =58,남영25례,녀영33례)、정상출생체중조(n=180,남영99명,녀영81명)화고출생체중조(n =28,남영16례,녀영12례).채용방사면역분석법측정제대혈수소수평.채용독립양본t검험、Pearson상관분석、다원선성회귀분석진행수거통계.결과 여정상출생체중조[(9±5)μg/L]상비,저출생체중조제대혈수소수평[(7±5)μg/L]명현강저(t=3.216,P＜0.05),고출생체중조[(15±7)μg/L]명현승고(t=-4.026,P＜0.01).녀영제대혈수소수평[(11±6) μg/L]명현고우남영[(8±5)μg/L,t=-3.800,P＜0.0i].Pearson상관분석현시,제대혈수소수평여신생인출생체중、신장、체질지수화태반중량정현저정상관(r치분별위0.391、0.280、0.361、0.323,균P＜0.01).교정모친년령、임신전체질지수、신생인성별화태령후,제대혈수소수평잉여출생체중정직선정상관(r2 =0.289,P＜0.01).결론 제대혈수소수평여신생인출생체중정정상관,유망작위반영신생인궁내생장발육적일개객관지표.
Objective To explore the role of umbilical cord blood leptin in intrauterine growth so as to provide evidence for early intervention for metabolic diseases.Methods Two hundred and sixty-six healthy newborns (140 males,126 females,gestational age ＞ 37 weeks) and their healthy mothers were enrolled in this study. Birth weight,birth length,head circumference,and ponderal index were measured before the neonates were assigned to low birth weight ( LBW ),normal birth weight ( NBW ) and high birth weight (HBW) groups.The level of leptin in the umbilical cord plasma was assayed by radioimmunoassay (RIA).Student's t test,Pearson correlation analysis and multi factor line regression were used for data analysis.Results Leptin was significantly decreased in the LBW group ((7 ±5) μg/L) and increased in the HBW group ( (15 ±7) μg/L) when compared with the NBW group ((9 ±5) μg/L) (t values were 3.216 and - 4.026,respectively; both P ＜ 0.05 ).Leptin in female neonates ( ( 11 ± 6 ) μg,/L) was significantly higher than that in male neonates ( ( 8 ± 5 ) μg/L) ( t =- 3.800,P ＜ 0.01 ).In Pearson correlation analysis,leptin was positively correlated with birth weight,height,body mass index (BMI) and placental weight ( r values were 0.391,0.280,0.361 and 0.323,respectively; all P ＜ 0.01 ).After adjustment for maternal age,pre-pregnancy BMI,newborn gender and gestational age,leptin showed a liner relationship with birth weight.Conclusions The level of leptin in umbilical cord blood may be associated with birth weight and could be used as an indicator of intrauterine growth.
