CAJ | 학술논문

当前治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的绝大多数药物作用于气道内细胞所表达的受体.因为吸入治疗可以传送药物到关键靶位细胞,并且全身副作用较小,所以吸入治疗成为当前治疗COPD最有前途的治疗方式.β2肾上腺素受体激动剂和抗胆碱能药都靶向到大小气道平滑肌上自主神经受体,发挥支气管扩张作用,同时β2肾上腺素受体激动剂还可作用到炎症细胞等其他靶位细胞上的受体而发挥抗炎作用.糖皮质激素受体分布广泛,吸入治疗使用普遍.肺部还有许多其他受体靶位,包括趋化因子受体和孤儿受体等,相应药物正在临床开发.
당전치료만성조새성폐질병(chronic obstructive pulmonary disease,COPD)적절대다수약물작용우기도내세포소표체적수체.인위흡입치료가이전송약물도관건파위세포,병차전신부작용교소,소이흡입치료성위당전치료COPD최유전도적치료방식.β2신상선소수체격동제화항담감능약도파향도대소기도평활기상자주신경수체,발휘지기관확장작용,동시β2신상선소수체격동제환가작용도염증세포등기타파위세포상적수체이발휘항염작용.당피질격소수체분포엄범,흡입치료사용보편.폐부환유허다기타수체파위,포괄추화인자수체화고인수체등,상응약물정재림상개발.
Most of the drugs that are currently used to treat chronic obstructive pulmonary disease(COPD) interact with receptors expressed by cells in the airways. This makes inhaled delivery efficientbecause it reaches the key target cells and has a low risk of systemic side effects. Both β2-agonists andanticholinergics target autonomic receptors on airway smooth muscle of large and small airways,to developthe effect on bronchodilation. They also interact with receptors expressed on other important target cells,toshow anti-inflammatory effect. Glucocorticoid receptors (GR) are widely distributed so that they are bestgiven by inhalation to interact with intracellular GR in the respiratory tract and to avoid side effects fromactivation of GR in extrapulmonary tissues. There are many other receptor targets that have now beenidentified as these may be future targets for developing novel therapies for COPD.