CAJ | 학술논문

目的研究西安市帕金森病(PD)患者认知功能障碍特征及其影响因素.方法采用连续入组的方法 ,对2007年1-4月在西安市7家综合医院神经内科就诊的PD患者,应用简易精神状态量表(MMSE)和蒙特利尔认知评估(MOCA)评定整体认知功能,Fuld物体记忆测验评价延迟记忆,快速词汇测验评价语言流畅性,数字广度试验评价注意功能,积木试验评价视空间功能.结果共入选PD患者100例,其中男52例,女48例;年龄43～86(65.6±17.1)岁.以MMSE作为判断有无认知障碍的标准,16%的PD患者存在认知障碍;以MOCA作为判断有无认知障碍的标准,83%的PD患者存在认知障碍.PD患者MMSE或MOCA亚项评分下降幅度最大,低分率较高的认知域为计算力、短时记忆、视空间功能、抽象能力、注意和语言流畅性.logistic逐步回归分析发现与PD认知障碍相关的因素有文化程度(P=0.000)、发病年龄(P=0.039)和性别(P=0.018).结论 PD常合并认知障碍,且以计算、短时记忆、视空间、抽象、注意和语言流畅性障碍为主.高龄发病、低文化程度和女性PD患者更容易发生认知功能障碍.
목적 연구서안시파금삼병(PD)환자인지공능장애특정급기영향인소.방법 채용련속입조적방법 ,대2007년1-4월재서안시7가종합의원신경내과취진적PD환자,응용간역정신상태량표(MMSE)화몽특리이인지평고(MOCA)평정정체인지공능,Fuld물체기억측험평개연지기억,쾌속사회측험평개어언류창성,수자엄도시험평개주의공능,적목시험평개시공간공능.결과공입선PD환자100례,기중남52례,녀48례;년령43～86(65.6±17.1)세.이MMSE작위판단유무인지장애적표준,16%적PD환자존재인지장애;이MOCA작위판단유무인지장애적표준,83%적PD환자존재인지장애.PD환자MMSE혹MOCA아항평분하강폭도최대,저분솔교고적인지역위계산력、단시기억、시공간공능、추상능력、주의화어언류창성.logistic축보회귀분석발현여PD인지장애상관적인소유문화정도(P=0.000)、발병년령(P=0.039)화성별(P=0.018).결론 PD상합병인지장애,차이계산、단시기억、시공간、추상、주의화어언류창성장애위주.고령발병、저문화정도화녀성PD환자경용역발생인지공능장애.
Objective To study the characteristics and influencing factors of cognition on patients with Parkinson' s disease (PD) in Xi'an in order to provide evidence for early recognition and treatment of cognitive impairment on PD patients. Methods Clinically defined PD patients from 7 hospitals in Xi'an from Jan. to Apr. 2007 were assessed with mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) for whole cognitive function. Furthermore,Fuld object memory test (FOM) was used to assess delayed memory while rapid verbal retrieve (RVR) was used to assess language fluency. Digit span subtest was used to assess attention and building blocks was used to assess visual space function respectively. Results 100 PD patients were recruited,including 52 men and 48 women,from 43 to 86 years old (65.6±17.1). MMSE scores was used as the standard for Recognition,PD with cognitive impairment accounted for 16%. According to MOCA scores,with PD cognitive disturbances accounted for 83%. Ability for calculation,short-term memory,visual space function,abstract capability,attention and language fluency dysfunction were main cognitive disturbances of PD. Analysis from single factor logistic regression showed that education,age of onset and gender were closely related to the occurrence of cognitive impairment on PD patients. Conclusion Cognitive impairment was common in PD. Ability of calculation,short-term memory,visual space function,abstract capability,attention and language fluency dysfunction were main cognitive disturbances of PD. Cognitive impairment of PD was more likely to occur with low degree of education,late onset of PD,and being female.