CAJ | 학술논문

目的探讨职业接触二甲基氯化锡(TMT-cl)作业工人的生物学监测指标.方法利用气相色谱分析法,对发生TMT-cl中毒的5个企业接触TMT-cl的44名男性作业工人(接触组)和某食品厂50名工人(对照组)尿中TMT-cl水平和血清钾含量进行测定,并对使用的甲基硫醇锡热稳定剂或造粒料、废料中TMT-cl含量进行分析.结果重、中、轻度TMT-cl中毒患者尿中均检出TMT-cl,分别为(0.869±0.392)、(0.963±0.482)、(0.716±0.384)μg/L,与对照组比较,差异有统计学意义(P＜0.01),尿中TMT-cl与病情严重程度无明显的平行关系(F=1.88,P＞0.05);TMT-cl重度中毒者第4天尿中TMT-cl与第1天比较,差异无统计学意义(P＞0.05),而中、轻度TMT-cl中毒者第4大尿中TMT-cl与第1天比较明显下降,差异有统计学意义(P＜0.01);第21天,重、中、轻TMT-cl中毒者尿中TMT-cl明显高于接触反应组,差异有统计学意义(P＜0.01).接触组低血钾发生率77.3%,明显高于对照组,差异有统计学意义(P＜0.01);接触组平均血钾水平低于正常参考值(3.5 mmol/L),与对照组比较,差异有统计学意义(P＜0.01),且血钾水平与病情严重程度存在平行关系(F=4.45,P＜0.05).接触组尿中TMT-cl与血钾呈负相关(r=-0.4456,P＜0.01).结论尿中TMT-cl可作为TMT-cl中毒特异性接触指标;血钾可作为早期的生物监测指标,以发现早期中毒人群.
목적 탐토직업접촉이갑기록화석(TMT-cl)작업공인적생물학감측지표.방법 이용기상색보분석법,대발생TMT-cl중독적5개기업접촉TMT-cl적44명남성작업공인(접촉조)화모식품엄50명공인(대조조)뇨중TMT-cl수평화혈청갑함량진행측정,병대사용적갑기류순석열은정제혹조립료、폐료중TMT-cl함량진행분석.결과 중、중、경도TMT-cl중독환자뇨중균검출TMT-cl,분별위(0.869±0.392)、(0.963±0.482)、(0.716±0.384)μg/L,여대조조비교,차이유통계학의의(P＜0.01),뇨중TMT-cl여병정엄중정도무명현적평행관계(F=1.88,P＞0.05);TMT-cl중도중독자제4천뇨중TMT-cl여제1천비교,차이무통계학의의(P＞0.05),이중、경도TMT-cl중독자제4대뇨중TMT-cl여제1천비교명현하강,차이유통계학의의(P＜0.01);제21천,중、중、경TMT-cl중독자뇨중TMT-cl명현고우접촉반응조,차이유통계학의의(P＜0.01).접촉조저혈갑발생솔77.3%,명현고우대조조,차이유통계학의의(P＜0.01);접촉조평균혈갑수평저우정상삼고치(3.5 mmol/L),여대조조비교,차이유통계학의의(P＜0.01),차혈갑수평여병정엄중정도존재평행관계(F=4.45,P＜0.05).접촉조뇨중TMT-cl여혈갑정부상관(r=-0.4456,P＜0.01).결론 뇨중TMT-cl가작위TMT-cl중독특이성접촉지표;혈갑가작위조기적생물감측지표,이발현조기중독인군.
Objective To investigate suitable biomarkers for workers exposure to trimethyhin chloride (TMT-cl).Methods Urinary samples of 44 male workers from five TMT-cl occupational poisoning incidents were collected.Methyhin mereaptide stabilizers and waste plastics used in the incidents were also collected.The levels of TMT-cl in all the samples were determined by gas chromatography.The concentration of blood potassium for each poisonings was determined compared to control group (50 male workers of a food company),and the correlation between blood potassium and urinary TMT-cl were also determined.Results TMT-cl was detected in urine of all the poisonings.The results were (0.86±90.392) μg/L (severe poisoning),(0.963±0.482)μg/L (moderate poisoning),(0.716±0.384)μg/L (mild poisoning) respectively and the difference was statistically significant (P＜0.01).But the severity of the clinical status did not seem to be closely correlated to the level of urinary TMT-cl (F=1.88,P＞0.05).In the severe poisonings,there were no differences in urinary TMTcl on day 4 after poisoning from day 1 (P＞0.05).In contrast,urinary TMT-cl was decreased significantly on day 4 than on day 1 in mild and moderate poisonings (P＜0.01).On day 21,levels of urinary TMT-cl of all the poisonings were higher than those of the workers exposed to TMT-cl who had no clinical status (P＜0.01).Blood potassium levels of exposed group was 77.3% which was significantly lower than normal value (P＜0.01).The concentration of blood potassium was lower than normal value (3.5 mmol/L) and was correlated with the severity of the clinical status (F=4.45,P＜0.05).Level of urinary TMT-cl of exposed group was negatively correlated with blood potassium (r=-0.4456,P＜0.01).Conclusion Level of urinary TMT-cl can be used as exposure bionmrker of TMT-cl poisoning.Blood potassium is an early biomarker of effect for TMT-cl poisoning so as to find poisoning population early.