中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
11期
1315-1317
,共3页
高血压病%老年人%动态脉压%脉搏波传导速度%踝臂血压指数%颈动脉内-中膜厚度
高血壓病%老年人%動態脈壓%脈搏波傳導速度%踝臂血壓指數%頸動脈內-中膜厚度
고혈압병%노년인%동태맥압%맥박파전도속도%과비혈압지수%경동맥내-중막후도
Hypertension%Elderly%Ambulatory pulse pressure%Pulse wave velocity%Ankle-brachial index%Carotid intima-media thickness
目的 探讨老年原发性高血压病患者动态脉压、脉搏波传导速度及踝臂指数与颈动脉内-中膜厚度的关系.方法 根据动态血压测量的24h平均脉压(24 h mPP)结果将90例老年高血压病患者分为2组,A组24 h mPP≥60 mm Hg(1 mm Hg =0.133 kPa) (n =45),B组24 h mPP ＜60 mm Hg(n =45).2组患者均采用VP-1000动脉硬化测定仪测量臂踝脉搏波传导速度(baPWV)和踝臂血压指数(ABI),采用HD15100SONO-CT彩色多普勒超声检测仪测量颈动脉内-中膜厚度(IMT).分析24 h mPP、baPWV及ABI与IMT的关系.结果 A组24 h mPP为(65.4±6.6)mm Hg、B组24 h mPP为(51.3±5.0) mm Hg,A组的baP-WV高于B组[(1879±343) mm/s比(1667±32)mm/s]、ABI低于B组[(1.08±0.14)比(1.14±0.09)]、IMT值大于B组[(0.82±0.21)比(0.71±0.16)],差异有统计学意义(P＜0.05).直线相关分析示,24hmPP、baPWV与IMT值呈正相关(r=0.461,P＜0.01；r =0.402,P＜0.01),ABI与IMT值呈负相关(r=-0.267,P ＜0.05).多元逐步回归分析示,24 h mPP、血糖、baPWV是影响IMT的主要因素.结论 老年高血压病患者24 hmPP、baPWV、ABI、血糖与IMT相关,动态血压监测和无创动脉硬化检测可早期预测老年人动脉粥样硬化程度,尽早进行干预治疗,以降低心脑血管事件发生率.
目的 探討老年原髮性高血壓病患者動態脈壓、脈搏波傳導速度及踝臂指數與頸動脈內-中膜厚度的關繫.方法 根據動態血壓測量的24h平均脈壓(24 h mPP)結果將90例老年高血壓病患者分為2組,A組24 h mPP≥60 mm Hg(1 mm Hg =0.133 kPa) (n =45),B組24 h mPP ＜60 mm Hg(n =45).2組患者均採用VP-1000動脈硬化測定儀測量臂踝脈搏波傳導速度(baPWV)和踝臂血壓指數(ABI),採用HD15100SONO-CT綵色多普勒超聲檢測儀測量頸動脈內-中膜厚度(IMT).分析24 h mPP、baPWV及ABI與IMT的關繫.結果 A組24 h mPP為(65.4±6.6)mm Hg、B組24 h mPP為(51.3±5.0) mm Hg,A組的baP-WV高于B組[(1879±343) mm/s比(1667±32)mm/s]、ABI低于B組[(1.08±0.14)比(1.14±0.09)]、IMT值大于B組[(0.82±0.21)比(0.71±0.16)],差異有統計學意義(P＜0.05).直線相關分析示,24hmPP、baPWV與IMT值呈正相關(r=0.461,P＜0.01；r =0.402,P＜0.01),ABI與IMT值呈負相關(r=-0.267,P ＜0.05).多元逐步迴歸分析示,24 h mPP、血糖、baPWV是影響IMT的主要因素.結論 老年高血壓病患者24 hmPP、baPWV、ABI、血糖與IMT相關,動態血壓鑑測和無創動脈硬化檢測可早期預測老年人動脈粥樣硬化程度,儘早進行榦預治療,以降低心腦血管事件髮生率.
목적 탐토노년원발성고혈압병환자동태맥압、맥박파전도속도급과비지수여경동맥내-중막후도적관계.방법 근거동태혈압측량적24h평균맥압(24 h mPP)결과장90례노년고혈압병환자분위2조,A조24 h mPP≥60 mm Hg(1 mm Hg =0.133 kPa) (n =45),B조24 h mPP ＜60 mm Hg(n =45).2조환자균채용VP-1000동맥경화측정의측량비과맥박파전도속도(baPWV)화과비혈압지수(ABI),채용HD15100SONO-CT채색다보륵초성검측의측량경동맥내-중막후도(IMT).분석24 h mPP、baPWV급ABI여IMT적관계.결과 A조24 h mPP위(65.4±6.6)mm Hg、B조24 h mPP위(51.3±5.0) mm Hg,A조적baP-WV고우B조[(1879±343) mm/s비(1667±32)mm/s]、ABI저우B조[(1.08±0.14)비(1.14±0.09)]、IMT치대우B조[(0.82±0.21)비(0.71±0.16)],차이유통계학의의(P＜0.05).직선상관분석시,24hmPP、baPWV여IMT치정정상관(r=0.461,P＜0.01；r =0.402,P＜0.01),ABI여IMT치정부상관(r=-0.267,P ＜0.05).다원축보회귀분석시,24 h mPP、혈당、baPWV시영향IMT적주요인소.결론 노년고혈압병환자24 hmPP、baPWV、ABI、혈당여IMT상관,동태혈압감측화무창동맥경화검측가조기예측노년인동맥죽양경화정도,진조진행간예치료,이강저심뇌혈관사건발생솔.
Objective To investigate the association between ambulatory pulse pressure(24 h mPP),pulse wave veocity( PWV),ankle brachial index(ABI) and carotid intima-media thickness(IMT) in elderly patients with essential hypertension (EH).Methods Ninety elderly patients with EH were divided into 2 groups according to the 24 h mPP:group A (24 h mPP ≥ 60 mm Hg,n =45 ),greup B ( 24 h mPP ＜ 60 mm Hg,n =45 ).The PWV and ABI were measured by the VP-1000 fully automated analyzer,The IMT was measured by using ultrasonic diagneser (HD1S100SONO-CT).The association between 24 h mPP,baPWV,ABI and IMT was analyzed.Results The 24 h mPP in group A was (65.4 ±6.6)mm Hg and was (51.3 ±5.0) mm Hg in group B.The PWV in group A was significantly higher than that in group B ( P ＜ 0.05 ),The ABI in group A was significantly less than that in group B ( P ＜ 0.05 ),and the IMT in group A was significantly higher than that in group B ( P ＜ 0.05).Linear correlation analysis showed 24 h mPP and baPWV was positively sssociated with IMT (r =0.461,P＜0.01 ; r =0.402,P＜0.01),ABI was negatively associated with IMT (r=-0.267,P＜0.05).Multiple stepwise regression analysis showed 24 h mPP,GLU,baPWV the main factors affecting the IMT.Conclusions In elderly patients with EH,24 h mPP,baPWV,ABI and GLU are related to the development of carotid atheresclerosis and monitoring 24 h mPP,PWV and ABI can predict early atherosclerosis.Early prevention and treatment of atherosclerosis can reduce the incidence of cardiovascular events.
