中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
10期
1060-1063
,共4页
脉络膜新生血管化/药物疗法%近视,退行性/药物疗法%光化学疗法/方法%曲安奈德/治疗应用
脈絡膜新生血管化/藥物療法%近視,退行性/藥物療法%光化學療法/方法%麯安奈德/治療應用
맥락막신생혈관화/약물요법%근시,퇴행성/약물요법%광화학요법/방법%곡안내덕/치료응용
Choroidal neovascularization / drug therapy%Myopia%Degenerative / drug therapy%Photochemotherapy / methods%Triamcinolone acetonide / therapeutic applications
目的 观察玻璃体腔注射曲安奈德(triamcinolone acetonide TA)联合光动力疗法治疗高度近视脉络膜新生血管的临床疗效.方法 依据病史、年龄、症状及经视力、眼底检查、眼底彩色照相、荧光素眼底血管造影( FFA)、光相干断层扫描(OCT),确诊为高度近视脉络膜新生血管(CNV)的患者153例165只眼,随机分为A、B、C组,A组51例58只眼、B组51例54只眼、C组51例53只眼.A组采用玻璃体腔注射TA联合光动力疗法.B组采用单纯光动力疗法(PDT).C组采用单纯玻璃体腔注射TA的治疗方法.治疗后3、6个月随访.结果 末次随访时,矫正视力0.01～1.2.A组:51例58只眼中治愈25只眼占43.10％；好转27只眼47.37％;无效6只眼9.53％；总有效率90.47％;复发3只眼5.17％.B组51例54只眼中治愈9只眼16.67％;好转15只眼27.78％;无效30只眼55.55％;总有效率44.45％；复发13只眼24.07％.C组51例53只眼中治愈10眼18.88％;好转14只眼26.41％;无效29只眼54.71％;总有效率45.29％;复发14只眼26.41％.三组总有效率比较差异有统计学意义(u=2.05693 P＜0.05).结论 玻璃体腔注射TA联合光动力疗法治疗高度近视脉络膜新生血管疗效好,安全性高.解决了单一治疗中存在的诸多并发症及高复发率的难题.
目的 觀察玻璃體腔註射麯安奈德(triamcinolone acetonide TA)聯閤光動力療法治療高度近視脈絡膜新生血管的臨床療效.方法 依據病史、年齡、癥狀及經視力、眼底檢查、眼底綵色照相、熒光素眼底血管造影( FFA)、光相榦斷層掃描(OCT),確診為高度近視脈絡膜新生血管(CNV)的患者153例165隻眼,隨機分為A、B、C組,A組51例58隻眼、B組51例54隻眼、C組51例53隻眼.A組採用玻璃體腔註射TA聯閤光動力療法.B組採用單純光動力療法(PDT).C組採用單純玻璃體腔註射TA的治療方法.治療後3、6箇月隨訪.結果 末次隨訪時,矯正視力0.01～1.2.A組:51例58隻眼中治愈25隻眼佔43.10％；好轉27隻眼47.37％;無效6隻眼9.53％；總有效率90.47％;複髮3隻眼5.17％.B組51例54隻眼中治愈9隻眼16.67％;好轉15隻眼27.78％;無效30隻眼55.55％;總有效率44.45％；複髮13隻眼24.07％.C組51例53隻眼中治愈10眼18.88％;好轉14隻眼26.41％;無效29隻眼54.71％;總有效率45.29％;複髮14隻眼26.41％.三組總有效率比較差異有統計學意義(u=2.05693 P＜0.05).結論 玻璃體腔註射TA聯閤光動力療法治療高度近視脈絡膜新生血管療效好,安全性高.解決瞭單一治療中存在的諸多併髮癥及高複髮率的難題.
목적 관찰파리체강주사곡안내덕(triamcinolone acetonide TA)연합광동력요법치료고도근시맥락막신생혈관적림상료효.방법 의거병사、년령、증상급경시력、안저검사、안저채색조상、형광소안저혈관조영( FFA)、광상간단층소묘(OCT),학진위고도근시맥락막신생혈관(CNV)적환자153례165지안,수궤분위A、B、C조,A조51례58지안、B조51례54지안、C조51례53지안.A조채용파리체강주사TA연합광동력요법.B조채용단순광동력요법(PDT).C조채용단순파리체강주사TA적치료방법.치료후3、6개월수방.결과 말차수방시,교정시력0.01～1.2.A조:51례58지안중치유25지안점43.10％；호전27지안47.37％;무효6지안9.53％；총유효솔90.47％;복발3지안5.17％.B조51례54지안중치유9지안16.67％;호전15지안27.78％;무효30지안55.55％;총유효솔44.45％；복발13지안24.07％.C조51례53지안중치유10안18.88％;호전14지안26.41％;무효29지안54.71％;총유효솔45.29％;복발14지안26.41％.삼조총유효솔비교차이유통계학의의(u=2.05693 P＜0.05).결론 파리체강주사TA연합광동력요법치료고도근시맥락막신생혈관료효호,안전성고.해결료단일치료중존재적제다병발증급고복발솔적난제.
Objective To observe the clinical efficacy of intravitreal injection of triamcinolone acetonide (TA) combined photodynamic therapy (PDT) of choroidal revascularization (CNV) in high myopia.Methods Based on history,age,symptoms and by visual acuity,fundus examination,fundus photography,fundus fluorescein angiography (FFA),optical coherence tomography (OCT),high myopia diagnosed with choroidal neovascularization (CNV) of 153 patients (165 eyes) were randomly divided into group A,B and C.group A consisted of 51 cases (58 eyes),group B 51 cases (54 eyes),group C of 51 cases (53 eyes).Group A treated with intravitreal injection of TA combined with photodynamic therapy,group B with photodynamic therapy alone (PDT),group C with intravitreal injection of TA alone.All cases were follow-up 3,6 months after treatment.Results At the final follow up,corrected visual acuity was 0.01-1.2.In group A,58 eyes of 51 patients accounted for 43.10％ cured in 25 eyes,improved 27 for 47.37％,invalid 6 for 9.53％,the total effective rate 90.47％,5.17％ recurrence in 3 eyes.In group B,51 patients were cured 9 out of 54 eyes for 16.67％,27.78％ improvement in 15 eyes,55.55％ invalid in 30 eyes,total effective rate of 44.45％,recurrence 13 24.07％.In group C,53 eyes of 51 patients were cured in 10 eyes 18.88％,improved 14 eyes 26.41％,invalid 29eyes 54.71％,total effective rate of 45.29％,recurrence 14 26.41％.The total efficiency of the three groups had statistically significant difference (u =2.05693,P ＜0.05).Conclusions Intravitreous injection of TA combined photodynamic therapy for choroidal neovascularization in high myopia is effective and safe.It solves the problems that a single treatment exist many complications and high recurrence rate.
