中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
7期
629-631
,共3页
色谱法%高效液相%炎琥宁%更昔洛韦%配伍禁忌%稳定性
色譜法%高效液相%炎琥寧%更昔洛韋%配伍禁忌%穩定性
색보법%고효액상%염호저%경석락위%배오금기%은정성
Chromatography,high-performance liquid%Potassium sodium dehydroandrographolide succinate%Ganciclovir%lncompatibility%Stability
目的 考察注射用炎琥宁与注射液用更昔洛韦在5%葡萄糖注射液中的配伍稳定性.方法 在室温[(20±1)℃]下,采用反相高效液相色谱法-二极管阵列检测器同时测定炎琥宁与更昔洛韦配伍后0～8 h内的含量变化,并观察配伍液的外观及pH值.结果 检测波长为251 mm,炎琥宁的平均回收率为99.8%,峰面积相对标准偏差(RSD)为0.84%(n=9),更昔洛韦的平均回收率为99.7%,RSD为0.68%(n=9).8 h内配伍液的颜色、pH值以及炎琥宁与更昔洛韦的含量均变化较大.结论 在室温条件下,注射用炎琥宁与注射液用更昔洛韦不可以在5%葡萄糖注射液中配伍使用.
目的 攷察註射用炎琥寧與註射液用更昔洛韋在5%葡萄糖註射液中的配伍穩定性.方法 在室溫[(20±1)℃]下,採用反相高效液相色譜法-二極管陣列檢測器同時測定炎琥寧與更昔洛韋配伍後0～8 h內的含量變化,併觀察配伍液的外觀及pH值.結果 檢測波長為251 mm,炎琥寧的平均迴收率為99.8%,峰麵積相對標準偏差(RSD)為0.84%(n=9),更昔洛韋的平均迴收率為99.7%,RSD為0.68%(n=9).8 h內配伍液的顏色、pH值以及炎琥寧與更昔洛韋的含量均變化較大.結論 在室溫條件下,註射用炎琥寧與註射液用更昔洛韋不可以在5%葡萄糖註射液中配伍使用.
목적 고찰주사용염호저여주사액용경석락위재5%포도당주사액중적배오은정성.방법 재실온[(20±1)℃]하,채용반상고효액상색보법-이겁관진렬검측기동시측정염호저여경석락위배오후0～8 h내적함량변화,병관찰배오액적외관급pH치.결과 검측파장위251 mm,염호저적평균회수솔위99.8%,봉면적상대표준편차(RSD)위0.84%(n=9),경석락위적평균회수솔위99.7%,RSD위0.68%(n=9).8 h내배오액적안색、pH치이급염호저여경석락위적함량균변화교대.결론 재실온조건하,주사용염호저여주사액용경석락위불가이재5%포도당주사액중배오사용.
Objective To study the stability of potassium sodium dehydroandrographolide succinate for injection and ganciclovir for injection in 5% glucose injection. Methods At ambient temperature [ (20 ± 1)℃ ], the changes of the contents of potassium sodium dehydroandrographolide succinate and ganciclovir were determined simultaneously by HPLC-DAD, and the changes of apperance, pH value were observed within 8 hours. Results Significant changes were observed in the content, apperance and pH value for the mixed solution within 8 hours.Conclusion Potassium sodium dehydroandrographolide succinate for injection cannot be mixed with ganciclovir for injection in glucose injection at ambient temperature.
