CAJ | 학술논문

目的探讨Marchiafava-Bignami病(MBD)的临床及影像学改变.方法回顾性分析了7例MBD患者的临床和CT、MRI资料,包括病灶形态、分布、信号或密度改变等影像学特征:4例同时行CT和MRI检查,2例仅行CT检查,1例仅行MRJ检查.结果本组患者急性型5例,均表现为胼胝体肿胀及长T1、长T2信号改变,均有双侧脑室周围白质、额叶皮层下白质对称性累及:慢性型2例,胼胝体明显萎缩变薄,并呈长T1、长T2信号及FLAIR像点片状或线样低信号灶.5例患者DWI显示病灶区信号明显增高并有2例出现弥散受限改变.结论 MBD具有特征性MRJ表现,其影像学改变可能反映其临床及预后.
목적 탐토Marchiafava-Bignami병(MBD)적림상급영상학개변.방법 회고성분석료7례MBD환자적림상화CT、MRI자료,포괄병조형태、분포、신호혹밀도개변등영상학특정:4례동시행CT화MRI검사,2례부행CT검사,1례부행MRJ검사.결과 본조환자급성형5례,균표현위변지체종창급장T1、장T2신호개변,균유쌍측뇌실주위백질、액협피층하백질대칭성루급:만성형2례,변지체명현위축변박,병정장T1、장T2신호급FLAIR상점편상혹선양저신호조.5례환자DWI현시병조구신호명현증고병유2례출현미산수한개변.결론 MBD구유특정성MRJ표현,기영상학개변가능반영기림상급예후.
Objective To investigate the clillicoradiologic characteristics of MarchiafavaBignami disease (MBD). Methods The clinical and neuroimaging findings, including lesion morphorogy, distribution, signal intensity/density in 7 MBD patients were retmspectiVely analyzed.Diffusion-weighted imaging(DWI)was performed in 5 cases.Of the 7 cases,4 underwent both CT and MRI,2 only CT and 1 MRI. Results with extensive iso-or slightly hypo-intensity on T1-weighted images and hyper-intensity on T2-weighted images, 5 patients were manifested as acute onset, in which white matter (WM) was symmetrically involved in bilateral periventricular and frontal subconical regions. Punctate or linear hypo-intensity on FLAIR images was found in the atrophied corpus callosum in 1 case presented as chronic type, with scattered patchy hyper-intensity in periventricular WM and frontal subcortical WM. DWI showed markedly hyper-intensity with diffusion restriction in 2 cases in acute phase with apparent diffusion coefficient(ADC)values(0.52～0.55)×10-3 mm2/s.Brain atrophy was found in all the 7 patients. Conclusions The MRI features of MBD are characteristic and may be associated with the clinical spectrum and prognosis.