中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
13期
22-24
,共3页
肾功能%胰激肽原酶%糖尿病%糖尿病早期肾病
腎功能%胰激肽原酶%糖尿病%糖尿病早期腎病
신공능%이격태원매%당뇨병%당뇨병조기신병
Renal function%Kallidinogenase%Diabetes mellitus%Early diabetic kidney disease
目的 研究胰激肽原酶对糖尿痛早期肾病患者肾功能的影响.方法 将46例2型糖尿病患者随机分成两组,治疗组(胰激肽原酶组)26例,对照组20例,两组均行综合性治疗,治疗组同时加用胰激肽原酶治疗,监测3个疗程前后空腹血糖、餐后2 h血糖、糖化血清蛋白、总胆固醇、甘油三酯、血压、血液流变学各指标,24 h尿蛋白(24 h UALB)定量,并观察其肾组织高峰到达时间、10 min残留率及15 min残留率等指标的变化情况.结果 胰激肽原酶组可使2型糖尿病患者血液流变学各指标明显降低(P<0.01),血脂、血压下降亦显著(P<0.05),15 min残留率明显下降(左右肾均P<0.01),10 min残留率亦明显减少(左右肾均P<0.05),24 h UALB定量降低(P<0.01).结论 胰激肽原酶可有效地降低血液粘稠度,抑制血小板聚集,降低血脂、血压,改善糖尿病患者的分泌和排泄功能,减少尿蛋白的排出,促进糖尿病早期肾脏病变恢复.
目的 研究胰激肽原酶對糖尿痛早期腎病患者腎功能的影響.方法 將46例2型糖尿病患者隨機分成兩組,治療組(胰激肽原酶組)26例,對照組20例,兩組均行綜閤性治療,治療組同時加用胰激肽原酶治療,鑑測3箇療程前後空腹血糖、餐後2 h血糖、糖化血清蛋白、總膽固醇、甘油三酯、血壓、血液流變學各指標,24 h尿蛋白(24 h UALB)定量,併觀察其腎組織高峰到達時間、10 min殘留率及15 min殘留率等指標的變化情況.結果 胰激肽原酶組可使2型糖尿病患者血液流變學各指標明顯降低(P<0.01),血脂、血壓下降亦顯著(P<0.05),15 min殘留率明顯下降(左右腎均P<0.01),10 min殘留率亦明顯減少(左右腎均P<0.05),24 h UALB定量降低(P<0.01).結論 胰激肽原酶可有效地降低血液粘稠度,抑製血小闆聚集,降低血脂、血壓,改善糖尿病患者的分泌和排洩功能,減少尿蛋白的排齣,促進糖尿病早期腎髒病變恢複.
목적 연구이격태원매대당뇨통조기신병환자신공능적영향.방법 장46례2형당뇨병환자수궤분성량조,치료조(이격태원매조)26례,대조조20례,량조균행종합성치료,치료조동시가용이격태원매치료,감측3개료정전후공복혈당、찬후2 h혈당、당화혈청단백、총담고순、감유삼지、혈압、혈액류변학각지표,24 h뇨단백(24 h UALB)정량,병관찰기신조직고봉도체시간、10 min잔류솔급15 min잔류솔등지표적변화정황.결과 이격태원매조가사2형당뇨병환자혈액류변학각지표명현강저(P<0.01),혈지、혈압하강역현저(P<0.05),15 min잔류솔명현하강(좌우신균P<0.01),10 min잔류솔역명현감소(좌우신균P<0.05),24 h UALB정량강저(P<0.01).결론 이격태원매가유효지강저혈액점주도,억제혈소판취집,강저혈지、혈압,개선당뇨병환자적분비화배설공능,감소뇨단백적배출,촉진당뇨병조기신장병변회복.
Objective To investigate the impact of kallidinogenase on renal function in early diabetic kidney dis-ease. Methods Forty - six cases of patients suffered from type 2 diabetes mellitus were divided into two groups at random in which 26 cases served as observed group accepted kallidinogenasemedicationadditionally and the other 20 cases received comprehensive medication simultaneously. Fasting blood glucose, 2 hours postprandial blood glucose, glycosylated serum protein, total cholesterol, triglycerides, blood pressure, items of hemurheology, 24 - hour urine protein, time span of peak time, residual rate for 10 minutes and 15 minutes were record and compared before and after three cases of medication. Re-sults Indexes of hemorheoiogy decreased significantly after 3 causes of medication (P < 0. 01), blood lipid, and blood pressure also declined significantly(P <0.01). 15 minutes residual rate decreased significantly and I0 minutes residual rate also declined(P < 0. 01). The 24 - hour urinary protein reduced significantly(P < 0.01). Conclusions Kallidino-genase can effectively decrease blood viscosity and platelet aggregation, lowering blood lipids and blood pressure, improving the secretion and excretion function, reducing the discharge of urine protein and promote the resumption of diabetic kidney disease in early stage.
