CAJ | 학술논문

目的通过比较分析131Ⅰ对青少年和中老年甲状腺功能亢进(甲亢)的临床疗效,探讨131Ⅰ治疗青少年甲亢的可行性.方法 940例在山东大学齐鲁医院及山东省立医院进行131Ⅰ治疗的甲亢患者入选,按年龄分为3组,青少年组(<25岁):106例患者,中年组(25～60岁):768例,老年组(>60岁):66例.随访2年,分析3组的疗效差异.结果青少年组痊愈46例(43.4%),好转34例(32.1%),甲减24例(22.6%),无效2例(1.9%),有效率为98.1%;中年组痊愈346例(45.1%),好转260例(33.9%),甲减140例(18.2%),无效22例(2.9%),有效率为97.1%;老年组痊愈28例(42.4%),好转24例(36.4%),甲减10例(15.2%),无效4例(6.1%),有效率为93.9%.X2检验显示各年龄组问痊愈率、好转率、甲减率、无效率之间差异均无统计学意义(均P>0.05).结论青少年甲亢患者接受131Ⅰ治疗效果与中老年患者无差异,131Ⅰ治疗青少年甲亢是有效、可行的.
목적 통과비교분석131Ⅰ대청소년화중노년갑상선공능항진(갑항)적림상료효,탐토131Ⅰ치료청소년갑항적가행성.방법 940례재산동대학제로의원급산동성립의원진행131Ⅰ치료적갑항환자입선,안년령분위3조,청소년조(<25세):106례환자,중년조(25～60세):768례,노년조(>60세):66례.수방2년,분석3조적료효차이.결과 청소년조전유46례(43.4%),호전34례(32.1%),갑감24례(22.6%),무효2례(1.9%),유효솔위98.1%;중년조전유346례(45.1%),호전260례(33.9%),갑감140례(18.2%),무효22례(2.9%),유효솔위97.1%;노년조전유28례(42.4%),호전24례(36.4%),갑감10례(15.2%),무효4례(6.1%),유효솔위93.9%.X2검험현시각년령조문전유솔、호전솔、갑감솔、무효솔지간차이균무통계학의의(균P>0.05).결론 청소년갑항환자접수131Ⅰ치료효과여중노년환자무차이,131Ⅰ치료청소년갑항시유효、가행적.
Objective To investigate the efficacy and safety of131 I therapy on hyperthyroidism in adolescents,middle-aged people,and the elderly.Methods 940 patients with hyperthyroidism,106 aged <25(Group A,group of young people),768 aged 25-60(Group B,middle-aged group),and 66 aged >60(Group C,group of the elderly),underwent131 I therapy and were followed up for2 years to evaluate the efficacy and safety.Results Forty-six patients in group A(43.4%)became euthyroid,34(32.1%)turned beaer,24(22.6%)suffered from hypothyroidism,and 2(1.9%)remained un-changed,with a general effective rate of 98.11%(104/106).346 patients(45.1%)in Group B became euthyroid,260(33.9%)turned better,140(18.2%)suffered from hypothyroidism,and 22(2.9%)remained unchanged,with a general effective rate of 97.14%(746/768).And28 patients(42.4%)in Group C became euthyroid,24(36.4%)turned better,10(15.15%)suffered from hypothyroidism,and4(6.1%)remained unchanged,with a general effective rate of 93.93%(62/66).There were not significant differences in the recovery rate,improvement rate,hypothyroidism rat,and ineffective rate among the 3 groups(all P>0.05).Conclusion There are no significant differences in the efficacy and safety of131 I therapy in hyperthyroidism on the patients of different ages,including adolescent,adult and elder persons.131I therapy is safe and effective for adolescents.