CAJ | 학술논문

目的观察氧气吸入联合放松训练治疗广泛性焦虑障碍( GAD)的疗效.方法将188例GAD患者随机分为治疗组及对照组,2组患者均常规给予帕罗西汀治疗,治疗组在此基础上辅以氧气吸入及放松训练,对照组则视病情辅以苯二氮卓类药物口服.于治疗前、治疗4周后分别采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)中的疗效总评部分(GI)及治疗意外症状量表(TESS)评价2组患者临床疗效及不良反应情况,并比较治疗前、后2组患者呼吸、心率及血压等生理指标变化情况.结果 2组患者HAMA评分均于治疗第2周明显下降(P＜0.05),第3周、第4周时亦显著低于治疗前水平(P＜0.05)；治疗组HAMA评分在治疗第1周、第2周时较对照组显著降低,治疗第3周、第4周时组间差异无统计学意义(P＞0.05)；2组患者GI评分均较治疗前明显降低(P＜0.05),并且以治疗组的降低幅度相对较显著(P＜0.05)；2组患者不良反应情况均较轻微,其TESS评分组间差异无统计学意义(P＞0.05).结论在常规药物治疗基础上辅以氧气吸入及放松训练,可迅速改善GAD患者焦虑症状、提高疗效,并且治疗过程中无明显不良反应,患者治疗依从性较好.
목적 관찰양기흡입연합방송훈련치료엄범성초필장애( GAD)적료효.방법 장188례GAD환자수궤분위치료조급대조조,2조환자균상규급여파라서정치료,치료조재차기출상보이양기흡입급방송훈련,대조조칙시병정보이분이담탁류약물구복.우치료전、치료4주후분별채용한밀이돈초필량표(HAMA)、림상료효총평량표(CGI)중적료효총평부분(GI)급치료의외증상량표(TESS)평개2조환자림상료효급불량반응정황,병비교치료전、후2조환자호흡、심솔급혈압등생리지표변화정황.결과 2조환자HAMA평분균우치료제2주명현하강(P＜0.05),제3주、제4주시역현저저우치료전수평(P＜0.05)；치료조HAMA평분재치료제1주、제2주시교대조조현저강저,치료제3주、제4주시조간차이무통계학의의(P＞0.05)；2조환자GI평분균교치료전명현강저(P＜0.05),병차이치료조적강저폭도상대교현저(P＜0.05)；2조환자불량반응정황균교경미,기TESS평분조간차이무통계학의의(P＞0.05).결론 재상규약물치료기출상보이양기흡입급방송훈련,가신속개선GAD환자초필증상、제고료효,병차치료과정중무명현불량반응,환자치료의종성교호.
Objective To observe the therapeutic effects of oxygen inhalation combined with relaxation training on patients with generalized anxiety disorder (GAD). Methods A total of 188 GAD patients were divided into the study group and the control group randomly.The two groups were treated with conventional antianxiety drugs (paroxetine),in addition to conventional medical therapy.The study group was aided with oxygen inhalation and relaxation training,the control group was given benzodiazepine.The scores of Hamilton anxiety rating scale (HAMA),global improvement(GI) [ a part of clinical global impression (CGI) ],and treatment emergent symptom scale (TESS) were used to evaluate clinical effects and adverse reactions before and after 4-week treatment.The indexes of breathing,heart rate and blood pressure were evaluated before and after treatment. Results The scores of HAMA scale and GI in the two groups were significantly different after treatment( P ＜ 0.05 ),and the study group changed significantly( P ＜ 0.05 or P ＜ 0.01 ). The adverse reactions of the two groups were slight,there was no significant difference of TESS before and after treatment ( P ＞ 0.05 ). There was no significant difference in terms of breathing,heart rate and blood pressure between the two groups before treatment( P ＞ 0.05 ),but were all lower after treatment the study group changed more apparently and significantly(P ＜ 0.01 ). Conclusions Based on conventional drugs treatment oxygen inhalation combined with relaxation training could improve anxiety and somatization rapidly,there was no obvious adverse reaction and the patients compliance was good,so the treatment was worth to use in clinic.