中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2010年
3期
232-234
,共3页
刘金波%邓华聪%李丙蓉%兰丽珍%郑宏庭%诸葛福媛%吕智美
劉金波%鄧華聰%李丙蓉%蘭麗珍%鄭宏庭%諸葛福媛%呂智美
류금파%산화총%리병용%란려진%정굉정%제갈복원%려지미
脂联素%C反应蛋白%细胞间黏附分子1%糖尿病
脂聯素%C反應蛋白%細胞間黏附分子1%糖尿病
지련소%C반응단백%세포간점부분자1%당뇨병
Adiponectin%C-reactive protein%Soluble intercellular adhesion molecule-1%Diabetes mellitus
通过转染表达人全长脂联素基因的重组腺病毒载体来提高2型糖尿病大鼠血清脂联素水平.结果表明脂联素干预组血清可溶性细胞间黏附分子1(sICAM-1)和C反应蛋白(CRP)水平较糖尿病组明显下降[(18.73±4.66对23.60±4.25)mg/L和(14.91±1.79对19.09±2.95)ng/ml,均P＜0.01],提示提高循环脂联素水平可改善糖尿病炎症反应状态.
通過轉染錶達人全長脂聯素基因的重組腺病毒載體來提高2型糖尿病大鼠血清脂聯素水平.結果錶明脂聯素榦預組血清可溶性細胞間黏附分子1(sICAM-1)和C反應蛋白(CRP)水平較糖尿病組明顯下降[(18.73±4.66對23.60±4.25)mg/L和(14.91±1.79對19.09±2.95)ng/ml,均P＜0.01],提示提高循環脂聯素水平可改善糖尿病炎癥反應狀態.
통과전염표체인전장지련소기인적중조선병독재체래제고2형당뇨병대서혈청지련소수평.결과표명지련소간예조혈청가용성세포간점부분자1(sICAM-1)화C반응단백(CRP)수평교당뇨병조명현하강[(18.73±4.66대23.60±4.25)mg/L화(14.91±1.79대19.09±2.95)ng/ml,균P＜0.01],제시제고순배지련소수평가개선당뇨병염증반응상태.
Type 2 diabetic rats were treated with recombiriant adenovirus expressing human adiponectin (Ad-APN).The results showed that the levels of both plasma C-reactive protein and soluble intercellular adhesion molecule-1 were significantly decreased in Ad-APN-treated diabetic rats compared with those of diabetic rats [(18.73±4.66 vs 23.60±4.25)mg/L and (14.91±1.79 vs 19.09±2.95) ng/ml,both P＜0.01].These results suggest that increased serum concentration of adiponectin may improve the status of inflammation in diabetes mellitus.
