CAJ | 학술논문

前B细胞克隆增强因子(pre-B cell colony-enhancing factor,PBEF)最初是从人类外周血淋巴细胞中分泌的细胞因子样分子,最近发现PBEF也是一种新的具有结合并激活胰岛素受体、模拟胰岛素作用的脂肪细胞因子.PBEF还具有其他多种生物学活性,如调控B细胞分化、延缓中性粒细胞凋亡、参与炎症和免疫应答,可能参与了多种疾病的发生,比如急性肺损伤(acute lung injury,ALI)、脓毒症、冠状动脉粥样硬化、早产、糖尿病、癌症等,在急性肺损伤中具有生物标志作用.目前PBEF在机体内的具体作用机制尚不十分清楚,但其发现可能为研究相关疾病的发病机制及诊断与治疗提供新的思路.
전B세포극륭증강인자(pre-B cell colony-enhancing factor,PBEF)최초시종인류외주혈림파세포중분비적세포인자양분자,최근발현PBEF야시일충신적구유결합병격활이도소수체、모의이도소작용적지방세포인자.PBEF환구유기타다충생물학활성,여조공B세포분화、연완중성립세포조망、삼여염증화면역응답,가능삼여료다충질병적발생,비여급성폐손상(acute lung injury,ALI)、농독증、관상동맥죽양경화、조산、당뇨병、암증등,재급성폐손상중구유생물표지작용.목전PBEF재궤체내적구체작용궤제상불십분청초,단기발현가능위연구상관질병적발병궤제급진단여치료제공신적사로.
Pre-B-cell colony-enhancing factor (PBEF) is considered originally as cytokine-like molecule secreted by lymphocyte from human peripheral blood.PBEF has been recently identified as a new adipocytokine exerting insulin-mimetic effects by binding to the insulin receptor.PBEF also presents a variety of other biological activations,such as inducing B-cell differentiation,inhibiting neutrophil apoptosis,affecting immune and inflammatory functions,accordingly involving in several diseases such as acute lung injury (ALI),sepsis,atherosclerosis,pre-term labor,diabetes and cancer.It plays as a role of novel biomarker in ALI.Although the molecular mechanisms in the pathogenesis of these diseases are unknown,the discovery of PBEF may provide new idea and tool for studying the mechanisms of some diseases and their diagnosis and treatment.