CAJ | 학술논문

目的探讨白细胞介素-18(IL-18)及血管内皮生长因子(VEGF)对卵巢过度刺激综合征(OHSS)的预测价值.方法体外受精-胚胎移植(IVF-ET)患者66例,按采卵日是否发生OHSS及高危因素分为正常组、高危组和OHSS组.采卵日收集3组患者血清和卵泡液标本,酶联免疫吸附法(ELISA)测定IL-18和VEGF水平,分析其对卵巢过度刺激综合征(OHSS)的预测价值.结果 OHSS组血清和卵泡液IL-18水平分别为(646±203)ng/L和(885±345)ng/L,明显高于高危组和正常组(P<0.01);OHSS组血清和卵泡液VEGF水平分别为(286±108)ng/L和(985±214)ng/L,明显高于高危组和正常组(P<0.01).结论 OHSS患者血清和卵泡液IL-18及VEGF水平明显升高,说明IL-18和VEGF在OHSS的发生、发展中具有一定作用,测定采卵日血清和卵泡液IL-18及VEGF水平,对预测OHSS的发生有一定作用.
목적 탐토백세포개소-18(IL-18)급혈관내피생장인자(VEGF)대란소과도자격종합정(OHSS)적예측개치.방법 체외수정-배태이식(IVF-ET)환자66례,안채란일시부발생OHSS급고위인소분위정상조、고위조화OHSS조.채란일수집3조환자혈청화란포액표본,매련면역흡부법(ELISA)측정IL-18화VEGF수평,분석기대란소과도자격종합정(OHSS)적예측개치.결과 OHSS조혈청화란포액IL-18수평분별위(646±203)ng/L화(885±345)ng/L,명현고우고위조화정상조(P<0.01);OHSS조혈청화란포액VEGF수평분별위(286±108)ng/L화(985±214)ng/L,명현고우고위조화정상조(P<0.01).결론 OHSS환자혈청화란포액IL-18급VEGF수평명현승고,설명IL-18화VEGF재OHSS적발생、발전중구유일정작용,측정채란일혈청화란포액IL-18급VEGF수평,대예측OHSS적발생유일정작용.
Objective To determine the role of interleukin-18(IL-18) and vascular endothelial growth factor (VEGF) in the ovari-an hyperstimulation syndrome (OHSS) development. Methods Serum and follicular IL-18 and VEGF levels were measured with ELISA in 66 IVF patients, who were divided into three study groups according to OHSS risk factors on the day of ovum retrieval and whether will devel-op OHSS in future or not. 20 patients had no OHSS risk factors (normal group), 28 patients had OHSS risk factors without developing OHSS (OHSS risk group) and 18 patients had OHSS risk factors and developing OHSS in future (OHSS group). Results Serum and follicular IL-18 levels in OHSS group were significantly higher than those of other two groups(P<0.01). Serum and follicular VEGF levels in OHSS group were also significantly higher than those of other two groups(P<0.01). Conclusion Serum and follicular IL-18 and VEGF levels in OHSS group increased significantly, which suggested IL-18 and VEGF were positive correlated with OHSS development. And follicular IL-18 and VEGF levels in serum on the day of ovum retrieval have a prediction role in OHSS development.