陕西师范大学学报：自然科学版
陝西師範大學學報：自然科學版
협서사범대학학보：자연과학판
Journal of Shaanxi Normal University： Nat Sci Ed
2011年
4期
65-68
,共4页
酵母油脂%不饱和脂肪酸%多不饱和脂肪烯烃%软胶囊%降血脂
酵母油脂%不飽和脂肪痠%多不飽和脂肪烯烴%軟膠囊%降血脂
효모유지%불포화지방산%다불포화지방희경%연효낭%강혈지
yeast lipid%unsaturated fatty acid%polyunsaturated aliphatic alkene%soft capsale%cholesterol lowering function
采用GC-MS法分析啤酒酵母油脂中的主要成分和含量.观察酵母油脂复合软胶囊对高血脂大鼠的血清TC、TG、HDL-C水平的影响,评估酵母油脂复合软胶囊的辅助降血脂功能.用高脂饲料饲喂Wistar大鼠建立高血脂模型,再以0.15 g/kg bw0、.30 g/kg bw及0.90 g/kg bw剂量的受试物灌胃,高脂对照组灌胃给予同体积的食用花生油,灌胃量均为0.5 mL/100g bw,每日一次,连续35 d,取尾血测定各项血脂指标.结果表明,3种啤酒酵母均以多不饱和脂肪烯烃为主要成分,含量分别为37.74%、28.30%、26.63%;其次为不饱和脂肪酸,含量依次为27.83%、23.42%、30.75%.降血脂功能试验表明,与高脂对照组相比,酵母油脂复合软胶囊低、中、高剂量组的大鼠血清TC下降百分率分别为8.33（、14.49%、15.94%,血清TG下降百分率分别为10.80%、17.07%、18.47%,血清HDL-C上升分别为0.05 mmol/L、0.06 mmol/L0、.07 mmol/L.酵母油脂复合软胶囊具有辅助降血脂功能.
採用GC-MS法分析啤酒酵母油脂中的主要成分和含量.觀察酵母油脂複閤軟膠囊對高血脂大鼠的血清TC、TG、HDL-C水平的影響,評估酵母油脂複閤軟膠囊的輔助降血脂功能.用高脂飼料飼餵Wistar大鼠建立高血脂模型,再以0.15 g/kg bw0、.30 g/kg bw及0.90 g/kg bw劑量的受試物灌胃,高脂對照組灌胃給予同體積的食用花生油,灌胃量均為0.5 mL/100g bw,每日一次,連續35 d,取尾血測定各項血脂指標.結果錶明,3種啤酒酵母均以多不飽和脂肪烯烴為主要成分,含量分彆為37.74%、28.30%、26.63%;其次為不飽和脂肪痠,含量依次為27.83%、23.42%、30.75%.降血脂功能試驗錶明,與高脂對照組相比,酵母油脂複閤軟膠囊低、中、高劑量組的大鼠血清TC下降百分率分彆為8.33（、14.49%、15.94%,血清TG下降百分率分彆為10.80%、17.07%、18.47%,血清HDL-C上升分彆為0.05 mmol/L、0.06 mmol/L0、.07 mmol/L.酵母油脂複閤軟膠囊具有輔助降血脂功能.
채용GC-MS법분석비주효모유지중적주요성분화함량.관찰효모유지복합연효낭대고혈지대서적혈청TC、TG、HDL-C수평적영향,평고효모유지복합연효낭적보조강혈지공능.용고지사료사위Wistar대서건립고혈지모형,재이0.15 g/kg bw0、.30 g/kg bw급0.90 g/kg bw제량적수시물관위,고지대조조관위급여동체적적식용화생유,관위량균위0.5 mL/100g bw,매일일차,련속35 d,취미혈측정각항혈지지표.결과표명,3충비주효모균이다불포화지방희경위주요성분,함량분별위37.74%、28.30%、26.63%;기차위불포화지방산,함량의차위27.83%、23.42%、30.75%.강혈지공능시험표명,여고지대조조상비,효모유지복합연효낭저、중、고제량조적대서혈청TC하강백분솔분별위8.33（、14.49%、15.94%,혈청TG하강백분솔분별위10.80%、17.07%、18.47%,혈청HDL-C상승분별위0.05 mmol/L、0.06 mmol/L0、.07 mmol/L.효모유지복합연효낭구유보조강혈지공능.
The lipid components extracted from brewer＇s yeast were analyzed by GC-MS.The hypolipidemic assistant function of the yeast lipid in soft capsules was evaluated by observing the level of TC,TG and HDL-C in blood of hyperlipoidemia Wistar rats influenced by the yeast lipid.The hyperlipoidemia model rats were established by feeding high cholesterol feeds.The test preparation were intragastrically administrated to the rats with the dose of 0.15 g/kg bw,0.30 g/kg bw and 0.90 g/kg bw respectively once a day,and continued for 35 days.The administrated volume of test preparation was 0.5 mL/100g bw.The hyperlipoidemia control groups were intragastric administrated by the same volume of edible peanut oil.The blood samples from the tail of rats were used for measuring indexes of blood cholesterol.The results of GC-MS analysis showed that the main component is polyunsaturated aliphatic alkene,and the content is 37.74%,28.30%,26.63% respectively in three different samples;The second component is unsaturated fatty acid,and the content is 27.83%,23.42%,30.75% respectively.The results of functional experiments indicated that the blood TC levels of low-dosage group,middle-dosage group and high-dosage group with yeast lipid soft capsules were decreased 8.33%,14.49% and15.94% respectively,the blood TG levels were decreased 10.80%,17.07% and 18.47% respectively,and the blood HDL-C levels were increased 0.05 mmol/L,0.06 mmol/L and 0.07 mmol/L respectively compared with the control group.These results indicated that the yeast lipid soft capsule has the hypolipidemic assistant function.
