CAJ | 학술논문

选取2003-11,2004-06在同仁医院住院的急性ST抬高性心肌梗死男性患者6例,平均年龄52.5岁,在经皮穿刺冠状动脉球囊成形处理和支架植入血运重建后,经患者及其家属知情同意,进行自体骨髓干细胞移植治疗,移植前1周皮下注射粒细胞集落刺激因子行干细胞动员,外周血CD34+细胞达到1%～3%时,采集从骨髓动员出来的外周血单个核细胞,进一步纯化后经球囊导管注入梗死相关血管.每半年随访1次,4年后心肌梗死面积在干细胞移植后3个月时平均下降42.7%的基础上进一步缩小8.03%,总梗死面积平均下降50.73%,心脏射血分数增加至55.4%,冠状动脉造影无严重狭窄和需要行血运重建的病变出现.
선취2003-11,2004-06재동인의원주원적급성ST태고성심기경사남성환자6례,평균년령52.5세,재경피천자관상동맥구낭성형처리화지가식입혈운중건후,경환자급기가속지정동의,진행자체골수간세포이식치료,이식전1주피하주사립세포집락자격인자행간세포동원,외주혈CD34+세포체도1%～3%시,채집종골수동원출래적외주혈단개핵세포,진일보순화후경구낭도관주입경사상관혈관.매반년수방1차,4년후심기경사면적재간세포이식후3개월시평균하강42.7%적기출상진일보축소8.03%,총경사면적평균하강50.73%,심장사혈분수증가지55.4%,관상동맥조영무엄중협착화수요행혈운중건적병변출현.
Six patients with ST segment elevated acute myocardial infarction (AMI), who were 52.5 years old in average, were enrolled and performed the treatment at Tongren Hospital from November 2003 to June 2004. Following percutanecus transluminal coronary angioplasty and stent revascularization, autologous bone marrow stem cell (BMSC) transplantation was performed after informed consent was obtained. Patients were subcutaneously injected with granulocyte colony-stimulating factor (G-CSF) at 1 week before transplantation. When CD34+ cells going up to 1%-3% in peripheral blood, mononuclear cells in peripheral blood were harvested,purified, and further infused into the infarcted related coronary artery with an over-the-wire balloon catheter. Following up was performed every half a year. Four years later, the infarcted area of these patients was further decreased by 8.03%, in the basic descent of 42.7% at 3 months averagely; total infracted area descent was 50.73%, but ejection fraction increased by 4.6% from 50.8%. There was no serious coronary artery restenosis and/or stenosis formation which need revascularization upon angiography.