中南大学学报(医学版)
中南大學學報(醫學版)
중남대학학보(의학판)
JOURNAL OF CENTRAL SOUTH UNIVERSITY（MEDICAL SCIENCES）
2007年
6期
931-937
,共7页
局灶性节段性肾小球硬化%肾病综合征%肾小球硬化指数%综合疗法%远期预后%美国黑人
跼竈性節段性腎小毬硬化%腎病綜閤徵%腎小毬硬化指數%綜閤療法%遠期預後%美國黑人
국조성절단성신소구경화%신병종합정%신소구경화지수%종합요법%원기예후%미국흑인
focal segmental glomerulosclerosis%nephrotic syndrome%glomerulosclerotic index%combined therapy%long-term prognosis%African-American children
本文将针对25年来治疗局灶性节段性肾小球硬化的一项区域性儿童肾脏病协作计划进行系统回顾.所有患儿经肾穿刺诊断为局灶性节段性肾小球硬化,其中大部分为美国黑人患儿,与之前报道的患同样疾病以白人为主体的患儿比较,他们的临床特点和远期预后均有不同.由于亚洲和非洲的肾病患儿局灶性节段性肾小球硬化的发生率均较高,因此中国患儿可能在疾病的临床特征、对治疗的反应和远期预后等方面与本文所讨论的美国黑人患儿类似.
本文將針對25年來治療跼竈性節段性腎小毬硬化的一項區域性兒童腎髒病協作計劃進行繫統迴顧.所有患兒經腎穿刺診斷為跼竈性節段性腎小毬硬化,其中大部分為美國黑人患兒,與之前報道的患同樣疾病以白人為主體的患兒比較,他們的臨床特點和遠期預後均有不同.由于亞洲和非洲的腎病患兒跼竈性節段性腎小毬硬化的髮生率均較高,因此中國患兒可能在疾病的臨床特徵、對治療的反應和遠期預後等方麵與本文所討論的美國黑人患兒類似.
본문장침대25년래치료국조성절단성신소구경화적일항구역성인동신장병협작계화진행계통회고.소유환인경신천자진단위국조성절단성신소구경화,기중대부분위미국흑인환인,여지전보도적환동양질병이백인위주체적환인비교,타문적림상특점화원기예후균유불동.유우아주화비주적신병환인국조성절단성신소구경화적발생솔균교고,인차중국환인가능재질병적림상특정、대치료적반응화원기예후등방면여본문소토론적미국흑인환인유사.
Lessons learned over 25 years from treating focal segmental glomerulosclerosis ( FSGS )in a regional pediatric nephrology program will be reviewed. In a cohort of children with biopsy-proven FSGS, consisting of a large percentage of African-American patients, the clinical characteristics and long-term outcomes are different from previously published data on mostly white children with the same condition. Because Asian and African children with nephrotic syndrome have the same higher incidence of FSGS, it is possible that Chinese children with FSGS have clinical characteristics, therapeutic responses, and long-term outcomes similar to African-American children as reviewed in this article.
