生理学报
生理學報
생이학보
ACTA PHYSIOLOGICA SINICA
2007年
6期
739-744
,共6页
guanfacine%α2A肾上腺素受体%空间学习%条件性恐惧记忆%大鼠
guanfacine%α2A腎上腺素受體%空間學習%條件性恐懼記憶%大鼠
guanfacine%α2A신상선소수체%공간학습%조건성공구기억%대서
guanfacine%α2A-adrenoceptors%spatial learning%fear conditioning%rats
α2A肾上腺素受体选择性激动剂guanfacine对空间工作记忆和选择性注意等前额叶皮层认知功能有重要的、有益的影响.然而,激活α2A受体对于依赖杏仁体和海马回路的恐惧记忆条件反射是否有影响,目前尚不清楚.本研究结果显示,全身给予guanfacine显著提高大鼠在Lashley迷宫中的空间学习能力:guanfacine组大鼠达到学会标准所需要的训练次数和所犯错误的次数显著少于生理盐水对照组大鼠.然而,guanfacine组大鼠场景和声音恐惧记忆的获得/巩固与对照组大鼠相比没有显著差异.结果提示,刺激α2A受体产生的有益效应是任务依赖的:guanfacine改善空间学习能力,但不影响恐惧记忆的获得/巩固.
α2A腎上腺素受體選擇性激動劑guanfacine對空間工作記憶和選擇性註意等前額葉皮層認知功能有重要的、有益的影響.然而,激活α2A受體對于依賴杏仁體和海馬迴路的恐懼記憶條件反射是否有影響,目前尚不清楚.本研究結果顯示,全身給予guanfacine顯著提高大鼠在Lashley迷宮中的空間學習能力:guanfacine組大鼠達到學會標準所需要的訓練次數和所犯錯誤的次數顯著少于生理鹽水對照組大鼠.然而,guanfacine組大鼠場景和聲音恐懼記憶的穫得/鞏固與對照組大鼠相比沒有顯著差異.結果提示,刺激α2A受體產生的有益效應是任務依賴的:guanfacine改善空間學習能力,但不影響恐懼記憶的穫得/鞏固.
α2A신상선소수체선택성격동제guanfacine대공간공작기억화선택성주의등전액협피층인지공능유중요적、유익적영향.연이,격활α2A수체대우의뢰행인체화해마회로적공구기억조건반사시부유영향,목전상불청초.본연구결과현시,전신급여guanfacine현저제고대서재Lashley미궁중적공간학습능력:guanfacine조대서체도학회표준소수요적훈련차수화소범착오적차수현저소우생리염수대조조대서.연이,guanfacine조대서장경화성음공구기억적획득/공고여대조조대서상비몰유현저차이.결과제시,자격α2A수체산생적유익효응시임무의뢰적:guanfacine개선공간학습능력,단불영향공구기억적획득/공고.
It is known that stimulation of the α2A-adrenoceptors(α2A-ARs)by the selective α2A-AR agonist guanfacine produces an important and beneficial influence on prefrontal cortical(PFC)cognitive functions such as spatial working memory and selective attention.However,it is unclear whether stimulation of the α2A-ARs has a similar effect on fear conditioning that involves the amygdala and hippocampus.Here,we show that systemically administered guanfacine significantly enhances spatial learning of rats in the Lashley maze:compared with controls,the rats treated with guanfacine required significantly fewer trials and made significantly fewer errors to reach learning criterion.However,guanfacine produced no effect on acquisition of contextual and auditory fear memories.The present study suggests that beneficial effect of α2A-AR stimulation is task-dependent:guanfacine improves spatial learning but not fear conditioning.
