CAJ | 학술논문

目的：研究神经节苷脂(GM-1)对早产儿颅内出血(intracranial hemorrhage，ICH)的临床疗效。方法：选择60例早产儿颅内出血随机分为治疗组(n=30)和对照组(n=30)。治疗组在综合治疗基础上加用GM-1。分析两组呼吸暂停的发生率和吸吮-吞咽能力，并分别在纠正胎龄40周和41周时测定新生儿神经行为评分(NBNA)。结果：治疗组NBNA评分两次均明显高于对照组(P均<0.01)。吸吮-吞咽能力明显优于对照组( P<0.01)，呼吸暂停发病率显著低于对照组(P<0.05)。结论：GM-1作为中枢神经系统损伤修复药物，对ICH的早产儿神经行为发育有促进作用，可显著降低其病死率和神经系统后遗症的发生率，提高生存质量。
목적：연구신경절감지(GM-1)대조산인로내출혈(intracranial hemorrhage，ICH)적림상료효。방법：선택60례조산인로내출혈수궤분위치료조(n=30)화대조조(n=30)。치료조재종합치료기출상가용GM-1。분석량조호흡잠정적발생솔화흡전-탄인능력，병분별재규정태령40주화41주시측정신생인신경행위평분(NBNA)。결과：치료조NBNA평분량차균명현고우대조조(P균<0.01)。흡전-탄인능력명현우우대조조( P<0.01)，호흡잠정발병솔현저저우대조조(P<0.05)。결론：GM-1작위중추신경계통손상수복약물，대ICH적조산인신경행위발육유촉진작용，가현저강저기병사솔화신경계통후유증적발생솔，제고생존질량。
Objective: To Study the clinical effect of ganglioside to treat the intracranial hemorrhage (ICH) in preterm children. Methods: 60 preterm children with ICH were divided into 治疗 treated group (n=30) and control group (n=30). On the basis of positive treatment, the first group were given the 治疗meanwhile. To observe the rates of apnea and the babies ability of suck and swallow between t he two groups. Neonatal behavior neurological assessments (NBNA) for all infants were performed separately in 40 weeks after correcting gestational age and in 41 weeks. Results:The NBNA scores of 治疗 group both in 40 weeks and 41 weeks were significantly higher than those o f control group (P<0.01). The infants ability of suck and swallow was better in 治疗 group than that in control group ( P<0.01). The rate o f apnea was lower in 治疗 group than that in control group (P<0.05). Conclusions:The 治疗 can treat effectively the ICH in preterm children. Early administration can promote development of the neurobehavioral, improve prognosis in the early life and the quality of their life.