CAJ | 학술논문

目的观察细辛水煎剂与硝苯地平伍用的镇痛作用.方法采用醋酸致小鼠扭体法.结果在研究不同剂量细辛对小鼠镇痛作用的实验中确定26.6mg/kg为阈下镇痛值.细辛26.6mg/kg和硝苯地平2.5mg/kg单用均无镇痛作用,而联用后有明显镇痛作用,扭体次数较蒸馏水组降低50%(P<0.01),与单用细辛组相比减少54%(P<0.01).结论硝苯地平可增强细辛水煎剂的镇痛作用,二者合用不失为一种有效的中西药结合组方的镇痛药.
목적관찰세신수전제여초분지평오용적진통작용.방법채용작산치소서뉴체법.결과재연구불동제량세신대소서진통작용적실험중학정26.6mg/kg위역하진통치.세신26.6mg/kg화초분지평2.5mg/kg단용균무진통작용,이련용후유명현진통작용,뉴체차수교증류수조강저50%(P<0.01),여단용세신조상비감소54%(P<0.01).결론초분지평가증강세신수전제적진통작용,이자합용불실위일충유효적중서약결합조방적진통약.
Objective To observe the analgesic action of combination of asarum decoction and nifedipine.Methods The method of stretching induced by acetic acid was adopted.Results 26.6mg/kg was demonstrated to be the subthreshold dose of asarum by the experiment of analgesic action of asarum with different dosages in mice.Neither sole asarum(26.6mg/kg) nor sole nifedipine(2.5mg/kg)had analgesic action, but the combination of asarum and nifedipine had significant analgesic action compared with the model control (P<0.01) and the sole asarum group (P<0.01). The stretching frequency of the mice was reduced by 50% and 54% respectively.Conclusion Nifedi pine can enhance the analgesic action of asarum decoction. Combined asarum and nifedipine can be applied as an efficient analgesic drug.