CAJ | 학술논문

目的:研究不同分型的慢性前列腺炎对精液质晕恶化的影响.方法:根据目前存在感染和(或)针对前列腺的自身细胞免疫反应情况,将49例慢性前列腺炎患者进行分组.健康正常的个体作为对照组.检查包括精子密度、死亡率、形态、前列腺与精囊标记物、抗精浆抗体、白细胞汁数与伴随的炎症前细胞因子.结果:最严重的畸形见于无明显感染而有针对前列腺的自身细胞免疫患者.此外,在此类患者的精浆中检测到炎症前细胞因子水平显著升高.结论:伴有针埘前列腺的自身细胞免疫反应的慢性前列腺炎患者的精液质量参数有重要改变,并因此而引起不育.
목적:연구불동분형적만성전렬선염대정액질훈악화적영향.방법:근거목전존재감염화(혹)침대전렬선적자신세포면역반응정황,장49례만성전렬선염환자진행분조.건강정상적개체작위대조조.검사포괄정자밀도、사망솔、형태、전렬선여정낭표기물、항정장항체、백세포즙수여반수적염증전세포인자.결과:최엄중적기형견우무명현감염이유침대전렬선적자신세포면역환자.차외,재차류환자적정장중검측도염증전세포인자수평현저승고.결론:반유침시전렬선적자신세포면역반응적만성전렬선염환자적정액질량삼수유중요개변,병인차이인기불육.
Objective:To investigate whether different type of chronic prostatitis could have a deleterious effect on semen quality. Methods: Forty-nine patients diagnosed as suffering from chronic prostatitis were included and di-vided into groups according to the presence of infection and/or cellular autoimmune response against prostate anti-gens. Healthy normal individuals were included as controls. Measurements for sperm concentration, motility, morphology, prostate and seminal vesicle markers, antisperm antibodies, white blood cells and pro-inflammatory cytokines were performed accordingly. Results:The most severe abnormalities were found in patients with no evi-dent infection and an autoimmune response against prostate antigens. Moreover, significantly increased levels of pro-inflammatory cytokines were detected in seminal plasma from these patients. Conclusions: This study shows that chronic prostatitis patients with cellular autoimmune response to prostate antigens present important altera-tions in their semen quality parameters and may affect male fertility.