CAJ | 학술논문

给日本大耳白家兔每周2次肌注醋酸氢化可的松8mg*kg-1，造成激素性缺血性股骨头坏死的病理模型，通过设立骨复生组、模型对照组、空白对照组，观察血液流变学指标。结果发现骨复生具有降低全血低切粘度、血浆粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数及血浆纤维蛋白原含量的作用。这种调节作用可能是骨复生治疗激素性股骨头缺血坏死的机制。
급일본대이백가토매주2차기주작산경화가적송8mg*kg-1，조성격소성결혈성고골두배사적병리모형，통과설립골복생조、모형대조조、공백대조조，관찰혈액류변학지표。결과발현골복생구유강저전혈저절점도、혈장점도、홍세포압적、홍세포취집지수、홍세포강성지수급혈장섬유단백원함량적작용。저충조절작용가능시골복생치료격소성고골두결혈배사적궤제。
To study the influence of GUFUSHENG on blood rheology of rabbits with Steroid-induced Avascular Necrosis of Femoral Head, 30 white Japanese rabbits with big ear were divided into 3 groups randomly: GUFUSHENG group and two control group ( model group, blank group). Except for the blank group, the others were made pathological models by injecting hydrocortisone acetate twice every week. After completing the modeling process, the indexes of blood rheology were analyzed. The results showed that GUFUSHENG could lower the whole blood viscosity, plasma viscosity, hematocrit, hemagglutination index, erythrocyte fragility index, and the level of plasma fibrinogen, which might be the mechanism of curing steroid-induced Avascular Necrosis Head of Femoral Head with GUFUSHENG.