CAJ | 학술논문

目的观察γ干扰素治疗恶性胸腹腔积液的疗效。方法经病理或细胞学证实的恶性胸腹水患者56例，尽量抽(放)净患者胸腹水后，胸腹腔内注入γ干扰素200～300万U+0.9%盐水20ml，视胸腹水多少，5～10天后再重复治疗。结果恶性胸水患者46例，CR：17(37.0%)，RP：17(37.0%)，NC：12(26.0%)，总有效率：CR+PR：34(74.0%)。恶性腹水患者10例，CR：2例，PR：4例，NC：4例。结论γ干扰素治疗恶性胸腹腔积液发挥了生物反应调节剂局部治疗的优势，是治疗恶性胸腹水的又一有效药物。
목적관찰γ간우소치료악성흉복강적액적료효。방법경병리혹세포학증실적악성흉복수환자56례，진량추(방)정환자흉복수후，흉복강내주입γ간우소200～300만U+0.9%염수20ml，시흉복수다소，5～10천후재중복치료。결과악성흉수환자46례，CR：17(37.0%)，RP：17(37.0%)，NC：12(26.0%)，총유효솔：CR+PR：34(74.0%)。악성복수환자10례，CR：2례，PR：4례，NC：4례。결론γ간우소치료악성흉복강적액발휘료생물반응조절제국부치료적우세，시치료악성흉복수적우일유효약물。
Objective　To evaluate the efficacy of interferon-γ (IFN-γ) for malignant pleual and peritoneal effusions. Methods　56 patients with malignat effusion including 46 cases of pleural effusion and 10 cases of peritoneal effusion, were diagnosed by cytology or pathology or AFP positive. (2～3)×106U of IFN-γ was injected into pleural or peritoneal cavity after the effusion was drained up. The treatment could be repeated 5-10 days later according to the amount of the effusion.Results　46 patients with pleural effusion showed CR 17 cases (37.0%), PR 17 cases (37.0%),NC 12 cases (26.0%); the total response rate was 74.0%. 10 patients with peritoneal effusion showed CR 2/10, PR 4/10, NC 4/10. Conclusion　INF-γ is one of selective treatments for malignant pleural and peritoneal effusions.