CAJ | 학술논문

目的探讨局部应用人纤维蛋白胶(FS)对实验性肝损伤的止血和护创作用。方法采用大鼠肝表面裂伤(Ⅰ型)和部分肝切除断面伤(Ⅱ型)模型，以自然止血法为阴性对照，缝合止血法和凝血酶止血法为阳性对照，比较各组间创面止血时间和术后d 1、4、7、14及50光镜下创面愈合情况。结果与自然止血组相比，FS组对Ⅰ型肝损伤模型止血时间平均缩短86.0%(P＜0.01)，对Ⅱ型肝损伤模型缩短79.0%(P＜0.01)；与凝血酶止血法相比，FS组止血时间分别缩短45.0%和84.0%(P＜0.01和P＜0.05)。肉眼和镜下观察，FS组创面愈合较快，局部组织损伤较轻，术后50 d腹腔粘连基本消失。结论 FS对大鼠肝损伤有明显止血作用，并能促进创伤的愈合。
목적탐토국부응용인섬유단백효(FS)대실험성간손상적지혈화호창작용。방법채용대서간표면렬상(Ⅰ형)화부분간절제단면상(Ⅱ형)모형，이자연지혈법위음성대조，봉합지혈법화응혈매지혈법위양성대조，비교각조간창면지혈시간화술후d 1、4、7、14급50광경하창면유합정황。결과여자연지혈조상비，FS조대Ⅰ형간손상모형지혈시간평균축단86.0%(P＜0.01)，대Ⅱ형간손상모형축단79.0%(P＜0.01)；여응혈매지혈법상비，FS조지혈시간분별축단45.0%화84.0%(P＜0.01화P＜0.05)。육안화경하관찰，FS조창면유합교쾌，국부조직손상교경，술후50 d복강점련기본소실。결론 FS대대서간손상유명현지혈작용，병능촉진창상적유합。
Purpose　The aim is to investigate the hemostatic and protective effect of fibrin sealant(FS) on liver trauma in rats.Methods　On the surface of cracked wound(type Ⅰ) and resected wound(type Ⅱ)，spraying of FS or thrombin or direct suturation, was used receptively. Natural hemostasis was used as control.During postoperation the hemostatic time and the state of wound healing on 1st, 4th, 7th,14th, 50th day were observed.Results　Compared with the natural hemostasis,the hemostatical time of the FS group was shorter 86.0%(P＜0.01)in liver trauma type Ⅰ and 79.0%(P＜0.01)in liver trauma type Ⅱ.Compared with the thrombin group,the hemostatical time of the FS group was shorten 45.0%(P＜0.01)in liver trauma type Ⅰ and 84.0%(P＜0.05) in liver trauma type Ⅱ.The wound surface of FS group was healed faster than that of other groups.Conclusion　FS was an effective hemostatic and healing-promoter on liver trauma of rats.